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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Biosciences & Biotechnology Laboratory » Research » Publications at this Location » Publication #363994

Research Project: Non-antibiotic Strategies to Control Enteric Diseases of Poultry

Location: Animal Biosciences & Biotechnology Laboratory

Title: Submission of genome sequences of Clostridium perfringens strain LLY_Tpel17 into genBank database

item Li, Charles
item Yan, Xianghe
item Lillehoj, Hyun

Submitted to: Genbank
Publication Type: Database / Dataset
Publication Acceptance Date: 8/26/2019
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Necrotic enteritis (NE) is an important enteric disease in poultry, which is responsible for annual losses of more than US $6 billion to the world poultry industry. Clostridium perfringens (CP) type A/G strains are the primary etiology. Pathogenic CP can result in sudden death or production losses characterized by poor feed conversion and growth rate. Increase in the incidence of NE during recent decades has been associated with withdrawal of antibiotics growth-promotors (AGP) from poultry feed. With the increasing regulatory pressure on AGPs in agricultural animal production, it is essential to understand the disease-causing mechanism before developing effective control measures. Scientists from ARS at Beltsville, MD, extracted bacterial DNA from these virulent CP strains, sequenced and analyzed the whole genomes of CP Tpel17 strains. This genome contains NetB, TpeL and other virulence factors. Availability of the genomic information in public database will help the relevant scientific community improve their understanding of infection mechanism at the molecular level, and will provide further insights into future vaccine design to combat NE, and into selection of optimal challenge strains to evaluate the efficacies of antibiotics alternative approaches.