Effect of dietary Magnolol/Honokiol on growth performance and anti-oxidant status in broiler chickens infected with experimental necrotic enteritis

Authors: OH, SUNGTAEK - US Department Of Agriculture (USDA); LEE, YOUNGSUB - US Department Of Agriculture (USDA); Lillehoj, Hyun

Submitted to: Poultry Science Meeting
Publication Type: Abstract Only
Publication Acceptance Date: 5/1/2018
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Effects of dietary Magnolol/Honokiol on growth performance and antioxidant status in broiler chickens infected with experimental necrotic enteritis Sungtaek Oh, Youngsub Lee and Hyun S. Lillehoj: Animal Bioscience and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705. Magnolol/Honokiol (M/H) from magnolia tree bark has been widely used in traditional Asian medicine. However, no studies have been reported investigating the effects of dietary supplementation with magnolia bark extract in chickens. There are two primary aims of this study: 1. To investigate the growth promoting effects of dietary magnolia bark extract (M/H), and 2. To investigate the effects of dietary magnolia bark extract on host antioxidant response in broiler chickens which are experimentally infected with necrotic enteritis (NE). Total one-hundred sixty eight 1-day-old male broiler chicks were randomly divided into 6 experimental groups based on the dietary treatment as follow: (1) standard diet; (2) M/H low (standard diet with 0.333 mg/kg); (3) M/H high (standard diet with 0.555 mg/kg); (4) NE infection with standard diet; (5) NE infection with M/H low; (6) NE infection with M/H high. NE infection was induced with previously established co-infection model using E. maxima and C. perfingens. At 14 days of age, chickens were orally infected with E. maxima (1 x 104 oocysts/chicken) followed by C. perfringens infection (1 x 109 CFU/chicken) at 18 days of age to induce experimental NE. Growth performance increased between days 1 - 35 in uninfected and E. maxima/C. perfringens co-infected chickens fed with M/H low or M/H high diets compared with unsupplemented controls. Gut lesion scores were decreased, while a-1-AGP levels were unchanged, in co-infected chickens fed magnolia-supplemented diets vs. unsupplemented controls. In general, transcripts for antioxidant enzymes were increased in chickens fed with magnolia-supplemented diets compared with unsupplemented controls, and significant interactions between dietary supplementation and co-infection were observed for all antioxidant enzyme transcript levels. In summary, dietary Magnolol and Honokiol improved growth performance (FCR, feed intake, body weight and body weight gain), reduced gut lesion score, and decreased oxidative stress associated with NE. These findings will facilitate the development of new dietary strategies to improve poultry health, disease resistance and productivity without antibiotic growth promoters.