Submitted to: Genbank
Publication Type: Other
Publication Acceptance Date: 2/7/2017
Publication Date: N/A
Technical Abstract: Mammalian interleukin-7 (IL-7) is able to stimulate lymphocyte proliferation and maturation, and reverse immuno-suppression. However, whether poultry IL-7 has similar functions remains unclear. Chicken IL-7 promoted mouse B cell proliferation in vitro, and significantly reduced virus titer in bursal tissue and chicken morbidity. Mechanically, chIL-7 induced chicken lymphocyte proliferation and interferon-' production, but down-regulated TGF-ß expression. Mammalian interleukin-7 (IL-7) gene can enhance the immunogenicity of DNA vaccine.