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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Biosciences & Biotechnology Laboratory » Research » Publications at this Location » Publication #347333

Research Project: Non-antibiotic Strategies to Control Enteric Diseases of Poultry

Location: Animal Biosciences & Biotechnology Laboratory

Title: Submission of nucleotide sequence chicken IL-7 to genbank database

item Lillehoj, Hyun
item Panebra, Alfredo

Submitted to: Genbank
Publication Type: Other
Publication Acceptance Date: 2/7/2017
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Mammalian interleukin-7 (IL-7) is able to stimulate lymphocyte proliferation and maturation, and reverse immuno-suppression. However, whether poultry IL-7 has similar functions remains unclear. Chicken IL-7 promoted mouse B cell proliferation in vitro, and significantly reduced virus titer in bursal tissue and chicken morbidity. Mechanically, chIL-7 induced chicken lymphocyte proliferation and interferon-' production, but down-regulated TGF-ß expression. Mammalian interleukin-7 (IL-7) gene can enhance the immunogenicity of DNA vaccine.