Submitted to: Genbank
Publication Type: Other
Publication Acceptance Date: 1/31/2016
Publication Date: N/A
Technical Abstract: Poultry coccidiosis, caused by intestinal protozoa Eimeria, is a severe problem for the poultry industry, leading to a substantial economic burden of over three billion dollars worldwide. Conventional vaccines including live vaccines and attenuated vaccines could cause mild to severe reactions Numerous studies have demonstrated that host immunity to avian coccidiosis is complex and largely dependent on cell-mediated immunity (CMI). Apicomplexans possess a characteristic apical complex consisting of micronemes, rhoptries, dense granules, and other structural elements such as conoid, polar ring and subpellicular microtubules. Many secreted or membrane bound proteins, which are involvedin the interaction with the host immune system, are regarded as targets for immunological interventions. Until recently, some of immune regulator and effector genes that could influence host–parasite interaction at the molecular and cellular levels were identified. Profilin (3-1E) antigen is located on the surface of Eimeria sporozoites and schizonts. DNA vaccination with 3-1E gene could induce partial immune protection against coccidiosis, which indicated this protein was highly immunogenic. Eimeria profilin had high protective efficacy of vaccination on resistance to experimental E. acerulina challenge.