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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Parasitic Diseases Laboratory » Research » Publications at this Location » Publication #345672

Research Project: Evaluation of Swine Immunity and Development of Novel Immune and Genomic Intervention Strategies to Prevent and/or Treat Respiratory Diseases of Swine

Location: Animal Parasitic Diseases Laboratory

Title: Alternative strategies for the control and elimination of PRRS

Author
item Rowland, Raymond - Kansas State University
item Lunney, Joan

Submitted to: Veterinary Microbiology
Publication Type: Review Article
Publication Acceptance Date: 9/18/2017
Publication Date: 9/30/2017
Citation: Rowland, R.R., Lunney, J.K. 2017. Alternative strategies for the control and elimination of PRRS. Veterinary Microbiology. 209:1-4. https://doi.org/10.1016/j.vetmic.2017.09.006.
DOI: https://doi.org/10.1016/j.vetmic.2017.09.006

Interpretive Summary:

Technical Abstract: Porcine reproductive and respiratory syndrome (PRRS) is the most costly disease of modern global pig production systems. The etiological agent, PRRS virus (PRRSV), an RNA virus, was identified in Europe (PRRSV-1 isolates) in 1991, and later in the US (PRRSV-2 isolates). Modified live virus (MLV) vaccines are largely ineffective, particularly for the control of heterologous PRRSV infections. Unique features of the virus include a large degree of genetic variation along with the capacity to maintain a long-term subclinical infection. Persistence at the population level poses the greatest challenge for successful control and elimination. Biosecurity and vaccination have served as the major industry-wide control measures as producers wait for a new generation of vaccines still years away. In the absence of a new generation of vaccines, new strategies and technologies have emerged, which offer new opportunities to negate the impact of the disease. Novel alternative strategies for the control and elimination of PRRS are reviewed in this special issue of Veterinary Microbiology.