Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/1/2016
Publication Date: 2/1/2017
Publication URL: https://handle.nal.usda.gov/10113/6472243
Citation: Li, C.Z., Yan, X., Lillehoj, H.S. 2017. Draft genome sequences of clostridium perfringens strain LLY_N11, a pathogenic isolate of necrotic enteritis from a healthy chicken. Genome Announcements. 5:44. https://doi.org/10.1128/genomeA.01225-17.
Interpretive Summary: In response to the increasing concerns over the widespread antimicrobial resistant bacteria, governments from many countries are gradually adopted strict measures to withdraw growth-promoting antibiotic from the animal feed. In the meantime, incidences of infectious diseases are also rising which increase the economic cost in disease control after the antibiotic withdrawal. One of the top priority bacterial diseases in poultry farms is necrotic enteritis (NE) which is caused by intestinal bacteria called Clostridium perfringens (abbreviated as CP), characterized by high toxin production, intestinal disorders and growth under performance in poultry, as well as adverse impacts on human food safety. The ARS scientists isolated a bacterial strains from healthy chicken gut which were able to induce NE disease, extracted and sequenced the bacterial DNA. The sequencing results provide a valuable resource for understanding of the role of CP bacterial genes in NE disease mechanism and will aid in the putative vaccine design to control NE disease.
Technical Abstract: Clostridium perfringens strain LLY_N11 is a commensal bacterial isolate from a healthy chicken that produced a necrotic enteritis in experimental studies. Here we present the assembly and annotation of its genome, which may provide further insights into improved understanding of the molecular mechanism involved in NE pathogenesis.