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ARS Home » Pacific West Area » Parlier, California » San Joaquin Valley Agricultural Sciences Center » Crop Diseases, Pests and Genetics Research » Research » Publications at this Location » Publication #335498

Title: Development of genome-based anti-virulence therapeutics to control HLB

item Lin, Hong
item Shi, Xiangyang

Submitted to: International Research Conference on Huanglongbing
Publication Type: Abstract Only
Publication Acceptance Date: 12/15/2016
Publication Date: 2/6/2017
Citation: Lin, H., Shi, X. 2017. Development of genome-based anti-virulence therapeutics to control HLB. International Research Conference on Huanglongbing. p. 5-7.

Interpretive Summary:

Technical Abstract: Orthologous gene replacement technique has been developed to confirm functions of key virulence genes in 'Candidatus Liberibacters asiaticus'. These results facilitate the development of antivirulence drugs that specifically target functional domains of virulence gene products to disarm pathogenicity or reduce virulence. This genome-based antivirulence treatment will provide a new approach to mitigate disease. Research progress towards the development of a novel therapeutic strategy for HLB management will be presented.