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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Biosciences & Biotechnology Laboratory » Research » Publications at this Location » Publication #333533

Research Project: Functional Genomics Approaches for Controlling Diseases of Poultry

Location: Animal Biosciences & Biotechnology Laboratory

Title: Clostridium perfringens, necrotic enteritis and its vaccination in broiler chickens

Author
item Li, Charles
item Lillehoj, Hyun

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 10/21/2016
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Clostridium perfringens type A strains are the main etiological factors for necrotic enteritis (NE), one of the economically important gastrointestinal diseases in poultry responsible for the annual loss of 2 billion dollars in US poultry industry. NE has gained worldwide importance during the last decade. The increasing occurrence of NE is thought to be associated with withdrawal of antibiotic growth promoters from the feed. Many predisposing factors, such as high levels of proteins in the feed, coccidiosis co-infections, immunosuppression, have been found to enhance this disease occurrence. Several infection models will be discussed. C. perfringens culture supernatant infusion alone, in the absence of bacterial cells, was found to affect the pathways related to disease pathogenethesis by inducing expression of genes related to early immunomodulation, inflammation and cell death in the small intestine. Vaccination with modified toxins or other immunogenic antigens seems a logical strategy for such disease prevention. Several vaccine strategies are presented. The most important immunogenic and protective proteins have been tested in several vaccination studies, including alpha toxin and NetB toxin. The combinations of different immunogenic antigens including NetB toxin should be required to protect birds against the severe challenge. Key words: Clostridium perfringens, Necrotic Enteritis, Vaccine, Broiler Chickens