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ARS Home » Plains Area » Lubbock, Texas » Cropping Systems Research Laboratory » Livestock Issues Research » Research » Publications at this Location » Publication #328203

Research Project: Improving Immunity, Health, and Well-Being in Cattle and Swine

Location: Livestock Issues Research

Title: Influence of a Saccharomyces cerevisia fermentation product on the pathophysiological response to a combined intranasal bovine herpesvirus-1 and intratracheal Mannheimia haemolytica challenge in Holstein steers

Author
item Sharon, Kate - Texas Tech University
item Liang, Yu - Texas Tech University
item Hudson, Rachel - Texas Tech University
item Yoon, Iikyu - Diamond V Mills, Inc
item Scott, Mark - Diamond V Mills, Inc
item Sanchez, Nicole
item Broadway, Paul
item Carroll, Jeffery - Jeff Carroll
item Ballou, Micheal - Texas Tech University

Submitted to: Journal of Animal Science Supplement
Publication Type: Abstract Only
Publication Acceptance Date: 4/21/2016
Publication Date: 7/1/2016
Citation: Sharon, K.P., Liang, Y., Hudson, R.E., Yoon, I., Scott, M.F., Sanchez, N.C., Broadway, P.R., Carroll, J.A., Ballou, M.A. 2016. Influence of a Saccharomyces cerevisia fermentation product on the pathophysiological response to a combined intranasal bovine herpesvirus-1 and intratracheal Mannheimia haemolytica challenge in Holstein steers. Journal of Animal Science Supplement. 94(E-Supplement 5):45, Abstract#101.

Interpretive Summary:

Technical Abstract: The objective of this study was to determine the effects of supplementing a Saccharomyces cerevisiae fermentation product prototype (Prototype) on the pathophysiological response during a combined viral-bacterial respiratory challenge. Holstein steer calves (126.5±6.11kg; N=16) were completely randomized to treatments including 0 (CON) or 20g/head/d of Prototype (n=8). Calves were housed in open, dry lot corrals with 4 calves per pen (2 pens/treatment). Calves were offered ad libitum access to a 50/50 total mixed ration of a commercially available 16% crude protein pelleted calf grower and 18% CP chopped alfalfa hay. Treatments were top dressed for 30d. Orts were measured daily and the quantity of feed was adjusted for approximately 10% orts. Calves were moved to individual stanchions (2.13×0.76'm) in an enclosed barn, fitted with rectal temperature monitoring devices, and allowed 24h adaptation before initiating the respiratory challenge. All calves were challenged with 1.5x108 PFU/mL/nostril of bovine herpesvirus-1 cooper strain at -72h using a mucosal atomizer and with 106 CFU of M. haemolytica (MH) intratracheal at 0h. Blood samples were collected via jugular venipuncture at -96, -72, -48, -24, 0, 6, 24, 48, 72, 120, 168 and 240h relative to the MH challenge. Total leukocytes counts tended (P=0.063) to be greater at 24h among CON steers. Neutrophil:lymphocyte also tended to be greater (P=0.095) at 24 and 72h among CON steers. Monocyte phagocytosis of an environmental Escherichia coli tended (P=0.056) to be greater in steers fed the Prototype at 24h. Neutrophil oxidative burst to an environmental Escherichia coli tended (P=0.071) to be greater at 6h and was greater (P=0.011) at 168h among steers fed the Prototype. However, monocyte oxidative burst tended (P=0.052) to be greater among CON at 72h. Neutrophil L-selectin did not differ between treatments (P=0.515). Neither serum haptoglobin concentrations (P=0.773) nor rectal temperature (P=0.985) differed between treatments. These data demonstrate that the Saccharomyces cerevisiae fermentation product prototype may influence some acute leukocyte responses during a viral-bacterial respiratory challenge, but did not have strong influences on measures of inflammation or disease.