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Title: PRRSV and the pregnant female

item HARDING, JOHN - University Of Saskatchewan
item LADINIG, ANDREA - University Of Veterinary Medicine
item NOVAKOVIC, PREDRAG - University Of Saskatchewan
item DETMER, SUSAN - University Of Saskatchewan
item WILKINSON, JAMIE - University Of Alberta
item YANG, TIANFU - University Of Alberta
item Lunney, Joan
item PLASTOW, G - University Of Alberta

Submitted to: Advances in Pork Production
Publication Type: Review Article
Publication Acceptance Date: 1/16/2016
Publication Date: 1/16/2016
Citation: Harding, J., Ladinig, A., Novakovic, P., Detmer, S., Wilkinson, J., Yang, T., Lunney, J.K., Plastow, G. 2016. PRRSV and the pregnant female. Advances in Pork Production. 27:169-180.

Interpretive Summary: (none submitted)

Technical Abstract: The Pregnant Gilt Model (PGM) is substantially complete and has provided substantive deliverables for the swine industry in Canada and beyond. The success of the PGM was largely dependent on a team of more than 30 researchers, students and technicians, along with external collaborators and institutions including the Universities of Saskatchewan and Alberta, Fast Genetics Inc., PigGen Canada, Prairie Diagnostic Services, Livestock Gentec, the Vaccine and Infectious Disease Organization, Kansas State University, Beltsville Agricultural Research Center (USDA), and the University of Veterinary Medicine, Vienna. Funding for the project was provided by Genome Canada (administered by Genome Alberta) and the Saskatchewan Ministry of Agriculture and Food (administered by Genome Prairie). The PGM1 was the largest study of reproductive PRRS ever undertaken, which enabled the use a broad array of "omic" technologies (genomics, transcriptomics, proteomics, kinomics, and metabolomics) to investigate phenotypic and genotypic predictors of the severity of reproductive PRRS. Building on these results and using a refined animal model and earlier termination, a new experiment, the PGM2, will validate the genomic markers associated with viral load and fetal autolysis and investigate specific mechanisms underlying transplacental transmission and host responses occurring in the most susceptible (index) fetuses. Because PRRS is one of the most costly diseases affecting the global swine industry and vaccines are not 100% effective, alternative methods of control and prevention, such as identifying more resilient pigs, are warranted.