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ARS Home » Plains Area » Lubbock, Texas » Cropping Systems Research Laboratory » Livestock Issues Research » Research » Publications at this Location » Publication #315273

Research Project: Improving Immunity, Health, and Well-Being in Cattle and Swine

Location: Livestock Issues Research

Title: Acute and chronic stress models differentially impact the inflammatory and antibody titer responses to respiratory vaccination in naive beef steers

Author
item May, Nathan - West Texas A & M University
item Carroll, Jeffery - Jeff Carroll
item Sanchez, Nicole
item Roberts, Shelby - West Texas A & M University
item Hughes, Heather - West Texas A & M University
item Broadway, Paul
item Sharon, Kate - Texas Tech University
item Ballou, Michael - Texas Tech University
item Richeson, John - Texas Tech University

Submitted to: Journal of Animal Science Supplement
Publication Type: Abstract Only
Publication Acceptance Date: 3/22/2015
Publication Date: 7/1/2015
Citation: May, N.D., Carroll, J.A., Sanchez, N.C., Roberts, S.L., Hughes, H.D., Broadway, P.R., Sharon, K.P., Ballou, M.A., Richeson, J.T. 2015. Acute and chronic stress models differentially impact the inflammatory and antibody titer responses to respiratory vaccination in naive beef steers. Journal of Animal Science Supplement. 93 (E-Supplement 3):566, Abstract#505.

Interpretive Summary:

Technical Abstract: The objective of this research was to determine the effect of an acute vs. chronic stress model on serum antibody titer and acute phase responses. Seronegative beef steers (n=32; 209 +/- 8 kg) were stratified by body weight and assigned randomly to 1 of 3 treatments: 1) Chronic stress (CHR), 0.5 mg/kg BW dexamethasone (DEX) administered i.v. at 10am on days -3 to 0; 2) Acute stress (ACU), 0.5 mg/kg body weight DEX administered i.v. at 10am on day 0 only; or 3) Control (CON), no DEX. On day -4, steers were fitted with jugular catheters and placed into individual stanchions in an environmentally-controlled facility. At 12pm on day 0, steers were administered a modified-live virus respiratory vaccine containing isolates of infectious bovine rhinotracheitis virus (IBRV), bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV) and parainfluenza-3 virus (PI3V). On day 4, cattle were transported (177 km) to an isolated facility and housed in a single pen. Serum was harvested from day 0, 7, 14, 21, 28, 35, 42, and 56 and subsequently used to determine IBRV-, BVDV-, BRSV-, and PI3V-specific antibody titers. Additionally, serum from day -2, 0, 1, 3, 7, and 14 was used to quantify haptoglobin (Hp) and ceruloplasmin (Cp) concentrations. There was a trt × d interaction (P<0.01) such that CHR steers had a greater (P=0.07) BVDV antibody titer from day 14 to 28; whereas, CHR was greater (P=0.06) than ACU on day 56. Moreover, IBRV antibody titers were increased beginning on day 14 for CHR and d 28 for ACU, and remained elevated through day 56 compared to CON (P=0.03). Stress treatment altered Hp such that CON exhibited a greater (P<0.01) Hp concentration than CHR but was not different from ACU (P=0.16). On day 3, Cp was greatest for CON, intermediate for ACU, and least for CHR (trt × day; P=0.01). Results suggest that immunosuppressive conditions in CHR and ACU may have allowed enhanced viral replication from the vaccine, resulting in a greater antibody titer response. Data further indicate that DEX administration blunted the acute phase response and these alterations were particularly evident in the CHR stress model.