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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Biosciences & Biotechnology Laboratory » Research » Publications at this Location » Publication #313325

Title: Effect of dietary capsicum and turmeric oleoresins on host-pathogen interaction in experimental necrotic enteritis in three commercial broiler chicken breeds

item Lillehoj, Hyun
item KIM, JI EUN - US Department Of Agriculture (USDA)

Submitted to: American Society of Microbiologists Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: 2/5/2015
Publication Date: N/A
Publication URL:
Citation: N/A

Interpretive Summary:

Technical Abstract: Necrotic enteritis (NE) is among the most economically important enteric diseases affecting the poultry industry worldwide. In an effort to develop alternatives to antibiotics strategies to reduce the negative impact of NE to gut health, we investigated the efficacy of dietary phytonutrient mixture, Capsicum and Curcuma oleoresins on disease susceptibility to NE caused by co-infections with Eimeria maxima and Clostridium perfringens, and the role of gut microbiota community in three commercial broiler chicken breeds, Cobb, Ross and Hubbard. Dietary Capsicum and Curcuma oleoresins significantly improved body weights and reduced the gut lesions in all three breeds compared with their respective control groups (P<0.05). The results of pyrotag deep sequencing of the bacterial 16S rRNA gene showed that bacterial profiles in the ileum were quite distinct depend on the broiler breed type. Interestingly, Candidatus Arthromitus, one of segmented filamentous bacteria (SFB) involved in regulatingT cells on the mucosa surface, was commonly identified as a key gut microbe in untreated and uninfected (control group), untreated and infected (NE group) and treated and infected (NE + XT group) in Cobb and Hubbard broilers, and a Ross control group in, indicating a potential immune regulatory role of Candidatus Arthromitus in the ileum of three broiler breeds. These new findings increase our understanding of the positive effect of dietary phytonutrients as alternatives to antibiotics and the possible role of gut microbiota in local immune regulation in broiler chickens. This study is the first to report the effects of dietary phytonutrients on the differential immune modulatory role of gut microbiota in commercial broiler breeds and opens a new way to reduce the use of antibiotics in poultry disease control.