|MA, YIYI - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|TUCKER, KATHERINE - University Of Massachusetts|
|SMITH, CAREN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|LEE, YU-CHI - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|HUANG, TAO - Harvard School Of Public Health|
|Lai, Chao Qiang|
|RICHARDSON, KRIS - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 2/19/2014
Publication Date: 4/29/2014
Citation: Ma, Y., Tucker, K.L., Smith, C.E., Lee, Y., Huang, T., Lai, C., Parnell, L.D., Richardson, K., Ordovas, J.M. 2014. Lipoprotein lipase variants interact with polyunsaturated fatty acids to modulate obesity traits in Puerto Ricans. Journal of Federation of American Societies for Experimental Biology. 28:1037.7.
Technical Abstract: Lipoprotein lipase (LPL) is a candidate gene for obesity based on its role in triglyceride hydrolysis and the partitioning of fatty acids towards storage or oxidation. Whether dietary fatty acids modify LPL associated obesity risk is unknown. We examined five single nucleotide polymorphisms (SNPs) (rs320, rs2083637, rs17411031, rs13702, rs2197089) for potential interaction with dietary fatty acids for obesity traits in 1171 participants (333 men and 838 women, aged 45-75 y) of the Boston Puerto Rican Health Study (BPRHS). In women, SNP rs320 interacted with dietary polyunsaturated fatty acids (PUFA) for body mass index (BMI) (P=0.002) and waist circumference (WC) (P=0.001) respectively. Higher intake of PUFA was associated with lower BMI and WC in homozygotes of the major allele (TT) (P=0.01 and 0.005) but not in minor allele carriers (TG and GG). These interactions were replicated in an independent population, African American women of the Atherosclerosis Risk in Communities (ARIC) study (n=1334). To conclude, dietary PUFA modulated the association of LPL rs320 with obesity traits in two independent populations. These interactions may be relevant to the dietary management of obesity, particularly in women.