Location: Livestock Issues ResearchTitle: Effect of surgical castration with or without oral meloxicam on the acute inflammatory response in yearling beef bulls Author
|Roberts, Shelby - West Texas A & M University|
|Hughes, Heather - West Texas A & M University|
|Carroll, Jeffery - Jeff Carroll|
|Powell, Jeremy - University Of Arkansas|
|Hubbell, Donald - University Of Arkansas|
|Richeson, John - West Texas A & M University|
Submitted to: Proceeding of Plains Nutrition Council Symposium
Publication Type: Proceedings
Publication Acceptance Date: 4/1/2014
Publication Date: 6/1/2014
Citation: Roberts, S.L., Hughes, H.D., Sanchez, N.C., Carroll, J.A., Powell, J.G., Hubbell, D.S., Richeson, J.T. 2014. Effect of surgical castration with or without oral meloxicam on the acute inflammatory response in yearling beef bulls. Proceeding of Plains Nutrition Council Symposium. Pg. 61.
Technical Abstract: Pain management and welfare are increasingly prevalent concerns within animal agriculture and oral analgesics may alleviate the pain associated with castration. This study was conducted to elucidate the effects of surgical castration on the acute inflammatory response and immunomodulation and whether concurrent oral administration of meloxicam (1 mg/kg BW) ameliorates these responses. On day -1, crossbred bull calves (n=31; initial body weight = 227.4 ± 10.3 kilograms) were fitted with indwelling jugular cannulas and rectal temperature probes, placed into individual stanchions, and assigned randomly to 1 of 3 treatments. Treatment application occurred at hour 0 and consisted of: 1) intact bulls with sham castration (CON), 2) surgical castration (CAS), and 3) surgical castration with oral meloxicam (MEL). Blood samples were collected at 0.5-hour intervals from hour -2 to 4 hour, 1.0-hour intervals from hour 4 to 8 hours, and 12-hour intervals from hour 12 to 72 hours. Serum was analyzed for cortisol and haptoglobin (Hp) concentrations using ELISA. Whole blood was analyzed for complete blood cell counts at -2, 0, 2, 4, 6, 8, 12, 24, 36, 48, 60, and 72 hours. Post-castration rectal temperature was greatest for MEL, intermediate for CAS, and least for CON (P=0.01). Serum cortisol was increased (P<0.001) for CAS and MEL compared to CON during the post-castration period. At 0.5 and 1.5 hours, cortisol was greater in CAS and MEL than CON; whereas, at 2 and 2.5 hours CAS was greatest, MEL was intermediate and CON was least (trt x time; P<0.001). Total white blood cell (P=0.04), lymphocyte (P=0.02) and monocyte (P=0.002) counts were greatest for CAS, intermediate for MEL and least for CON. The change in serum Hp, relative to baseline values, was reduced for MEL at 36 (P<0.01) and 60 hours (P=0.03) and the overall Hp concentration was least for MEL (P<0.001). Oral administration of meloxicam altered the acute inflammatory response in castrates, as evidenced by a reduction in Hp and certain leukocyte concentrations. Nevertheless, further research is needed to determine if these alterations might impede convalescence from the castration procedure.