Location: Animal Parasitic Diseases LaboratoryTitle: New pieces of the Trichinella puzzle Author
|Pozio, Edoardo - Istituto Superiore Di Sanita|
Submitted to: International Journal for Parasitology
Publication Type: Literature Review
Publication Acceptance Date: 5/28/2013
Publication Date: 6/28/2014
Citation: Pozio, E., Zarlenga, D.S. 2013. New pieces of the Trichinella puzzle. International Journal for Parasitology. 2013 Nov; 43(12-13):983-987. Interpretive Summary:
Technical Abstract: Contrary to our understanding of just a few decades ago, the genus Trichinella now consists of a complex assemblage of no less than 9 different species and 3 additional genotypes whose taxonomic status remains in flux. New data and methodologies have allowed advancements in detection and differentiation at the population level which in turn have demonstrably advanced epidemiological, immunological and genetic investigations. In like manner, molecular and genetic studies have permitted us to hypothesize biohistorical events leading to the worldwide dissemination of this genus, and to begin crystalizing the evolution of Trichinella on a macro scale. The findings of species in countries and continents otherwise considered Trichinella-free have raised questions regarding host adaptation and associations, and advanced important findings on the biogeographical histories of its members. Using past reviews as a backdrop, we have ventured to present an up-to-date assessment of the taxonomy, phylogenetic relationships and epidemiology of the genus Trichinella with additional insights on host species, survival strategies in nature and the shortcomings of our current understanding of the epidemiology of the genus. In addition, we have begun compiling information available thus far on genomics, proteomics, transcriptomics and population studies of consequence in the hope we can build on this in years to come.