Location: Virus and Prion Research
Project Number: 5030-32000-231-094-A
Project Type: Cooperative Agreement
Start Date: Aug 1, 2022
End Date: Sep 30, 2023
To study influenza A virus at the human and swine interface.
Virus samples collected from existing surveillance networks will be characterized in vitro (sequencing and genetic analysis and antigenic assays) as an extension of these existing surveillance networks. Sequencing will explore new sequencing and computational platforms and computational platforms that allow full genome genetic characterization of viruses in under 12 hours directly from RNA extracted from swine influenza virus samples. Swine influenza A virus isolates will be assessed for antigenic relatedness to human vaccines to assess their pandemic potential. Some newly characterized viruses may be tested in the swine model to study their pathology and transmissibility in pigs.