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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Research Project #441215

Research Project: Efficacy of a Pan-genotypic Influenza A Virus Antisense Locked Nucleic Acid Oligonucleotide (LNA) as a Preventative and Therapeutic in Swine

Location: Virus and Prion Research

Project Number: 5030-32000-231-090-T
Project Type: Trust Fund Cooperative Agreement

Start Date: Jul 11, 2022
End Date: Jan 1, 2025

Determine the efficacy of a pan-genotypic influenza A virus antisense locked nucleic acid oligonucleotide (LNA) as a preventative and therapeutic in swine.

Two challenge studies with ~57 pigs per study will be conducted in which an LNA will be administered to swine either daily for three days before exposure (Study A; prevention) or daily starting a day after exposure (Study B; therapeutic) to influenza A virus. The following will be evaluated to determine the effectiveness of the LNA: Virus shedding via virus isolation/titration/PCR, gross lesions and histologic lesions.