Skip to main content
ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Research Project #437635

Research Project: Validation of a Live-Virus Vaccine Candidate for Efficient Attenuation and Better Protection

Location: Virus and Prion Research

Project Number: 5030-32000-230-068-R
Project Type: Reimbursable Cooperative Agreement

Start Date: Jun 1, 2021
End Date: May 31, 2024

Our goal is to validate and improve modified live-virus (MLV) PRRSV vaccine candidates that express replication-competent interferons (IFNs).

The objective will be met using the following approaches: 1) Examine the kinetics of the incorporated IFN expression in vivo, and its effect in potentiation of antiviral immunity. 2) Implement a reverse-genetic platform to efficiently rescue and attenuate field isolates as vaccine backbones for improving vaccine efficacy and safety. 3) Optimize adjuvant regulation for better growth performance of vaccinated piglets.