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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Research Project #436347

Research Project: Characterization of Virus Isolates in Support of Swine Influenza A Virus Surveillance and Diagnostics

Location: Virus and Prion Research

Project Number: 5030-32000-120-028-A
Project Type: Cooperative Agreement

Start Date: Sep 1, 2019
End Date: Jun 30, 2023

Objective:
Objective: Improve data analysis and reporting of genetic and antigenic characterization of influenza A viruses from diagnostic submissions and assess industry perceptions on the impact of influenza A virus in swine.

Approach:
The USDA influenza A virus surveillance in swine data stream comes largely through the Cooperator veterinary diagnostic laboratory. We have established baseline sequence analyses, reference antiserum panels for antigenic analysis, as well as infection and vaccine study models from which to evaluate further evolution of viruses identified in the surveillance system, in addition to avian or human viruses of potential risk to the swine population. From the sequence analysis, viruses with unique genetic characteristics may be selected for associated in vitro and in vivo study. Additionally, influenza A virus isolates may be identified through public health investigations of zoonotic transmission events or from the animal health sector for unusual phenotypes or evasion of vaccine immunity. The data generated are complex and require in-depth interpretation. This project will also work to improve data analysis, summary and visualization for swine veterinarians and other stake-holders. We will also assess industry perceptions on the impact of IAV in swine.