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ARS Home » Pacific West Area » Pullman, Washington » Animal Disease Research » Research » Research Project #433385

Research Project: Utilizing Bioinformatics and Genetic Transformation Approaches to Develop Novel Vaccines to Prevent Babesia bovis Acute Infection and Transmission

Location: Animal Disease Research

Project Number: 2090-32000-039-20-T
Project Type: Trust Fund Cooperative Agreement

Start Date: Feb 1, 2018
End Date: Feb 1, 2020

Objective:
Developing a recombinant dual vaccine against Babesia bovis able to prevent both, acute disease and parasite transmission in endemic areas, practical to be used in neglected endemic regions worldwide.

Approach:
We propose developing the following two specific aims: SA#1] Developing bioinformatics and experimental platforms for the identification and in vitro testing of antigens to be components of a cyto-adhesion and transmission blocking vaccine against B. bovis. SA#2] Testing subunit vaccines aimed at preventing acute babesiosis and transmission of B. bovis in cattle, based on the antigens selected in SA#1.