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ARS Home » Pacific West Area » Pullman, Washington » Animal Disease Research » Research » Research Project #433385

Research Project: Utilizing Bioinformatics and Genetic Transformation Approaches to Develop Novel Vaccines to Prevent Babesia bovis Acute Infection and Transmission

Location: Animal Disease Research

Project Number: 2090-32000-039-20-T
Project Type: Trust Fund Cooperative Agreement

Start Date: Feb 1, 2018
End Date: Jul 1, 2020

Developing a recombinant dual vaccine against Babesia bovis able to prevent both, acute disease and parasite transmission in endemic areas, practical to be used in neglected endemic regions worldwide.

We propose developing the following two specific aims: SA#1] Developing bioinformatics and experimental platforms for the identification and in vitro testing of antigens to be components of a cyto-adhesion and transmission blocking vaccine against B. bovis. SA#2] Testing subunit vaccines aimed at preventing acute babesiosis and transmission of B. bovis in cattle, based on the antigens selected in SA#1.