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ARS Home » Pacific West Area » Pullman, Washington » Animal Disease Research » Research » Research Project #433385

Research Project: Utilizing Bioinformatics and Genetic Transformation Approaches to Develop Novel Vaccines to Prevent Babesia bovis Acute Infection and Transmission

Location: Animal Disease Research

Project Number: 2090-32000-039-020-T
Project Type: Trust Fund Cooperative Agreement

Start Date: Feb 1, 2018
End Date: Jul 1, 2022

Objective:
Developing a recombinant dual vaccine against Babesia bovis able to prevent both, acute disease and parasite transmission in endemic areas, practical to be used in neglected endemic regions worldwide. PHASE 2 Validating and improve the protective efficacy of a dual recombinant vaccine against Babesia bovis that can prevent acute clinical disease and transmission of the parasite by ticks.

Approach:
We propose developing the following two specific aims: SA#1] Developing bioinformatics and experimental platforms for the identification and in vitro testing of antigens to be components of a cyto-adhesion and transmission blocking vaccine against B. bovis. SA#2] Testing subunit vaccines aimed at preventing acute babesiosis and transmission of B. bovis in cattle, based on the antigens selected in SA#1. PHASE 2 [1] validation of selected protective antigens to demonstrate their suitability to offer broad range protection against B. bovis isolates from Africa and other endemic areas in the world. [2] testing of a dual-acting babesiosis vaccine against African B. bovis isolate in a field trial to be conducted in Morocco.