Location: Animal Disease Research
Project Number: 2090-32000-040-006-T
Project Type: Trust Fund Cooperative Agreement
Start Date: Feb 1, 2018
End Date: Dec 31, 2023
Developing a recombinant dual vaccine against Babesia bovis able to prevent both, acute disease and parasite transmission in endemic areas, practical to be used in neglected endemic regions worldwide. PHASE 2 Validating and improve the protective efficacy of a dual recombinant vaccine against Babesia bovis that can prevent acute clinical disease and transmission of the parasite by ticks.
We propose developing the following two specific aims: SA#1] Developing bioinformatics and experimental platforms for the identification and in vitro testing of antigens to be components of a cyto-adhesion and transmission blocking vaccine against B. bovis. SA#2] Testing subunit vaccines aimed at preventing acute babesiosis and transmission of B. bovis in cattle, based on the antigens selected in SA#1. PHASE 2  validation of selected protective antigens to demonstrate their suitability to offer broad range protection against B. bovis isolates from Africa and other endemic areas in the world.  testing of a dual-acting babesiosis vaccine against African B. bovis isolate in a field trial to be conducted in Morocco.