Skip to main content
ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Research Project #443385
Research Project: Metabolic and Molecular Mechanisms of Healthspan

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Aging - (Book / Chapter)

Functional assessments of short-term spatial memory in the Dog Aging Project identify strong associations with age that are not moderated by body mass Reprint Icon - (Peer Reviewed Journal)
Hargrave, S.H., Keyser, A., Kristal, E., Alexander, G.E., Block, T.A., Bray, E.E., Douglas, L.E., Kennedy, B.S., Promislow, D., Raichlen, D.A., Mclean, E.L. 2025. Functional assessments of short-term spatial memory in the Dog Aging Project identify strong associations with age that are not moderated by body mass. GeroScience. 48(1):1-16. https://doi.org/10.1007/s11357-025-01867-4.

What is the Clinical Evidence to Support Off-Label Rapamycin Therapy in Healthy Adults? Reprint Icon - (Review Article)
Hands, J.M., Lustgarten, M., Frame, L., Rosen, B. 2025. What is the Clinical Evidence to Support Off-Label Rapamycin Therapy in Healthy Adults?. Aging. 17(8):2079-2088. https://doi.org/10.18632/aging.206300.

Computationally modeling the physiologic impact of the ratio of fats to carbohydrates in the diet on intake among metabolically healthy adults Reprint Icon - (Peer Reviewed Journal)
Martinez, M.F., Heneghan, J., Weatherwax, C., Moran, T.H., Burton-Freeman, B., Velmurugan, K., Ordovas, J.M., Bartsch, S.M., Shah, T.D., Lee, J., Booth, S.L., Kleinberg, S., Chin, K.L., De La Haye, K., Dibbs, A., Scannell, S.A., Lee, B.Y. 2025. Computationally modeling the physiologic impact of the ratio of fats to carbohydrates in the diet on intake among metabolically healthy adults. Current Developments in Nutrition. 9(7). https://doi.org/10.1016/j.cdnut.2025.107487.

Lessons for responsible geroscience from the history of longevity - (Review Article)

Hyperinsulinemia-induced upregulation of adipocyte TPH2 contributes to peripheral serotonin production, metabolic dysfunction, and obesity Reprint Icon - (Peer Reviewed Journal)
Park, B., Reeves, A., Zhu, Y., Wilson, R., Fernandes, S., Buhman, K., Lytle, K., Jensen, M., Greenberg, A. 2025. Hyperinsulinemia-induced upregulation of adipocyte TPH2 contributes to peripheral serotonin production, metabolic dysfunction, and obesity. Journal of Clinical Investigation. https://doi.org/10.1172/JCI190765.

Natural variation in age-related dopamine neuron degeneration is glutathione dependent and linked to life span Reprint Icon - (Peer Reviewed Journal)
Coleman, C.R., Pallos, J., Arreola-Bustos, A., Wang, L., Raftery, D., Promislow, D., Martin, I. 2024. Natural variation in age-related dopamine neuron degeneration is glutathione dependent and linked to life span. Proceedings of the National Academy of Sciences (PNAS). https://doi.org/10.1073/pnas.2403450121.

The companion dog as a model for inflammaging: a cross-sectional pilot study Reprint Icon - (Peer Reviewed Journal)
Schmid, S.M., Hoffman, J.M., Prescott, J., Ernst, H., Promislow, D., Creevy, K.E. 2024. The companion dog as a model for inflammaging: a cross-sectional pilot study. GeroScience. https://doi.org/10.1007/s11357-024-01217-w.

Systems biology approaches identify metabolic signatures of dietary lifespan and healthspan across species Reprint Icon - (Peer Reviewed Journal)
Hilsabeck, T., Narayan, V.P., Wilson, K.A., Carrera, E., Raftery, D., Promislow, D., Brem, R.B., Campisi, J., Kapahi, P. 2024. Systems biology approaches identify metabolic signatures of dietary lifespan and healthspan across species. Nature Communications. https://doi.org/10.1038/s41467-024-52909-y.