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Susan Noh
Animal Disease Research
Research Molecular Biologist

Phone: (509) 335-6162
Fax: (509) 335-8328

GAH 211, WSU
PULLMAN, WA 991646630
Projects
Development of Strategies to Control Tick-Borne Bacterial Pathogens of Livestock
Cooperative Agreement (A)
  Accession Number: 436638
Identification of Tick Colonization Mechanisms and Vaccine Development for Anaplasmosis
In-House Appropriated (D)
  Accession Number: 431740
A Novel Platform for Bovine Anaplasmosis Vaccine Development
Non-Assistance Cooperative Agreement (S)
  Accession Number: 436715

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
A porcine ligated loop model reveals new insight into the host immune response against Campylobacter jejuni Reprint Icon - (Peer Reviewed Journal)
Negretti, N.M., Ye, Y., Malavasi, L.M., Pokharel, S.M., Huynh, S., Noh, S., Gourley, C.R., Ragle, C.A., Bose, S., Looft, T.P., Parker, C., Clair, G., Adkins, J.N., Konkel, M.E. 2020. A porcine ligated loop model reveals new insight into the host immune response against Campylobacter jejuni. Gut Microbes. 12: e1814121. https://doi.org/10.1080/19490976.2020.1814121.
Anaplasma marginale outer membrane protein vaccine candidates are conserved in North American and South African strains Reprint Icon - (Peer Reviewed Journal)
Hove, P., Brayton, K.A., Lienbenberg, J., Pretorius, A., Oosthuizen, M.C., Noh, S.M., Collins, N.E. 2020. Anaplasma marginale outer membrane protein vaccine candidates are conserved in North American and South African strains. Ticks and Tick Borne Diseases. 11(4). https://doi.org/10.1016/j.ttbdis.2020.101444.
Quantitative analysis of Anaplasma marginale acquisition and transmission by Dermacentor andersoni fed in vitro Reprint Icon - (Peer Reviewed Journal)
Vimonish, R., Johnson, W.C., Mousel, M.R., Brayton, K.A., Scoles, G.A., Noh, S.M., Ueti, M.W. 2020. Quantitative analysis of Anaplasma marginale acquisition and transmission by Dermacentor andersoni fed in vitro. Scientific Reports. 10:740. https://doi.org/10.1038/s41598-019-57390-y.
Sequence and immunologic conservation of Anaplasma marginale OmpA within strains from Ghana as compared to the predominant OmpA variant Reprint Icon - (Peer Reviewed Journal)
Futse, J.E., Buami, G., Kayang, B.B., Koku, R., Palmer, G.H., Graca, T., Noh, S.M. 2019. Sequence and immunologic conservation of Anaplasma marginale OmpA within strains from Ghana as compared to the predominant OmpA variant. PLoS One. 14(7):e0217661. https://doi.org/10.1371/journal.pone.0217661.
Global dynamics of highly pathogenic avian influenza outbreaks between 2005 and 2016 - Focus on distance and rate of spread Reprint Icon - (Peer Reviewed Journal)
Awada, L., Tizzani, P., Noh, S.M., Ducrot, C., Ntsama, F., Caceres, P., Chalvet-Monfray, K. 2018. Global dynamics of highly pathogenic avian influenza outbreaks between 2005 and 2016 - Focus on distance and rate of spread. Transboundary and Emerging Diseases. 65(6):2006-2016. https://doi.org/10.1111/tbed.12986.
Differences in francisella tularensis subsp. novicida infection competence in cell lines from a natural vector and non-vector tick species Reprint Icon - (Peer Reviewed Journal)
Reif, K.E., Ujczo, J.K., Alperin, D.C., Noh, S.M. 2018. Differences in francisella tularensis subsp. novicida infection competence in cell lines from a natural vector and non-vector tick species. Scientific Reports. 8(1):12685. https://doi.org/10.1038/s41598-018-30419-4.
Engineering of obligate intracellular bacteria: progress, challenges and paradigms Reprint Icon - (Peer Reviewed Journal)
McClure, E.E., Oliva Chavez, A.S., Shaw, D.K., Carlyon, J.A., Ganta, R.R., Noh, S.M., Wood, D.O., Bavoil, P.M., Brayton, K.A., Pedra, J.H. 2017. Engineering of obligate intracellular bacteria: progress, challenges and paradigms. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro.2017.59.
A cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis Reprint Icon - (Peer Reviewed Journal)
Manjunatha, U.H., Vinayak, S., Zambriski, J., Chao, A.T., Sy, T.L., Noble, C.G., Bonamy, G.M., Kondreddi, R.R., Zou, B., Gedeck, P., Brooks, C.F., Herbert, G.T., Sateriale, A., Tandel, J., Noh, S.M., Lakshminarayana, S.B., Lim, S.H., Goodman, L.B., Bodenreider, C., Feng, G., Zhang, L., Blasco, F., Wagner, J., Leong, J.F., Striepen, B., Diagana, T.T. 2017. A cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis. Nature. https://doi.org/10.1038/nature22337.
Identification of a cell epitope that is globally conserved among outer membrane proteins (OMPs) OMP7, OMP8, and OMP9 of anaplasma marginale strains and with OMP7 from the A. marginale subsp. centrale vaccine strain - (Peer Reviewed Journal)
Deringer, J.R., Forero-Becerra, E.G., Ueti, M.W., Turse, J.E., Futse, J.E., Noh, S.M., Palmer, G.H., Brown, W.C. 2016. Identification of a cell epitope that is globally conserved among outer membrane proteins (OMPs) OMP7, OMP8, and OMP9 of anaplasma marginale strains and with OMP7 from the A. marginale subsp. centrale vaccine strain. Clinical and Vaccine Immunology. doi: 10.1128/CVI.00406-16.
Anaplasma marginale actively modulates vacuolar maturation during intracellular infection of its tick vector dermacentor andersoni - (Peer Reviewed Journal)
Magunda, F., Thompson Wright, C., Schneider, D.A., Noh, S.M. 2016. Anaplasma marginale actively modulates vacuolar maturation during intracellular infection of its tick vector dermacentor andersoni. Applied and Environmental Microbiology. doi: 10.1128/AEM.01030-16.
Disaggregating tropical disease prevalence by climatic and vegetative zones within tropical West Africa - (Peer Reviewed Journal)
Beckley, C.S., Shaban, S., Koku, R., Palmer, G.H., Hudak, A.T., Noh, S.M., Futse, J.E. 2016. Disaggregating tropical disease prevalence by climatic and vegetative zones within tropical West Africa. PLoS One. 11(3):e0152560.
Superinfection exclusion of the ruminant pathogen anaplasma marginale in the tick vector is dependent on time between exposures to the strains - (Peer Reviewed Journal)
Noh, S.M., Dark, M.J., Reif, K.E., Ueti, M.W., Kappmeyer, L.S., Scoles, G.A., Palmer, G.H., Brayton, K.A. 2016. Superinfection exclusion of the ruminant pathogen anaplasma marginale in the tick vector is dependent on time between exposures to the strains. Applied and Environmental Microbiology. 82(11):3217-3124.
The pathogen-occupied vacuoles of anaplasma phagocytophilum and anaplasma marginale interact with the endoplasmic reticulum - (Peer Reviewed Journal)
Truchan, H.K., Hebert, K.S., Cockburn, C.L., Magunda, F., Noh, S.M., Carlyon, J.A. 2016. The pathogen-occupied vacuoles of anaplasma phagocytophilum and anaplasma marginale interact with the endoplasmic reticulum. Frontiers in Cellular and Infection Microbiology. doi: 10.3389/fcimb.2016.00022.
The bacterial microbiome of dermacentor andersoni ticks influences pathogen susceptibility - (Peer Reviewed Journal)
Gall, C.A., Reif, K.E., Scoles, G.A., Mason, K.L., Mousel, M.R., Noh, S.M., Brayton, K.A. 2016. The bacterial microbiome of dermacentor andersoni ticks influences pathogen susceptibility. The ISME Journal: Multidisciplinary Journal of Microbial Ecology. doi: 10.1038/ismej.2015.266.
Primary structural variation in anaplasma marginale Msp2 efficiently generates immune escape variants - (Peer Reviewed Journal)
Graca, T., Paradiso, L., Broschat, S.L., Noh, S.M., Palmer, G.H. 2015. Primary structural variation in anaplasma marginale Msp2 efficiently generates immune escape variants. Infection and Immunity. 83(11):4178-84.
Subdominant outer membrane antigens in anaplasma marginale: conservation, antigenicity, and protective capacity using recombinant protein - (Peer Reviewed Journal)
Ducken, D.R., Brown, W.C., Alperin, D.C., Brayton, K.A., Reif, K.E., Turse, J.E., Palmer, G.H., Noh, S.M. 2015. Subdominant outer membrane antigens in anaplasma marginale: conservation, antigenicity, and protective capacity using recombinant protein. PLoS One. doi: 1371/journal.pone.0129309.
Colonization of epidermal tissue by Staphylococcus aureus produces localized hypoxia and stimulates secretion of antioxidant and caspase-14 proteins - (Peer Reviewed Journal)
Lone, A., Atci, E., Renslow, R., Beyenal, H., Noh, S.M., Fransson, B., Abu-Lail, N., Park, J., Gang, D.R., Call, D. 2015. Colonization of epidermal tissue by Staphylococcus aureus produces localized hypoxia and stimulates secretion of antioxidant and caspase-14 proteins. Infection and Immunity. 83(8):3026-34.
Staphylococcus aureus induces hypoxia and cellular damage in porcine dermal explants - (Peer Reviewed Journal)
Lone, A., Noh, S.M., Atci, E., Renslow, R., Fransson, B., Beyenal, H., Abu-Lail, N., Jeong-Jin, P., Gang, D.R., Call, D. 2015. Staphylococcus aureus induces hypoxia and cellular damage in porcine dermal explants. PLoS Pathogens. 83(6):2531-2541.
Linking human health and livestock health: a “one-health” platform for integrated analysis of human health, livestock health, and economic welfare in livestock dependent communitities - (Peer Reviewed Journal)
Thumbi, S.M., Njenga, K.M., Marsh, T., Noh, S.M., Otiang, E., Munyua, P., Ochieng, L., Ogola, E., Yoder, J., Audi, A., Montgomery, J., Palmer, G., Mcelwain, T. 2015. Linking human health and livestock health: a “one-health” platform for integrated analysis of human health, livestock health, and economic welfare in livestock dependent communitities. PLoS One. doi: 1371/journal.pone.0120761.
Restriction of francisella novicida genetic diversity during infection of the vector midgut - (Peer Reviewed Journal)
Reif, K.E., Palmer, G.H., Crowder, D.W., Ueti, M.W., Noh, S.M. 2014. Restriction of francisella novicida genetic diversity during infection of the vector midgut. PLoS Pathogens. doi: 10.1371/journal.ppat.1004499.
Knockout of an outer membrane protein operon of anaplasma marginale by transposon mutagenesis - (Peer Reviewed Journal)
Crosby, F.L., Wamsley, H.L., Pate, M.G., Lundgren, A.M., Noh, S.M., Munderloh, U.G., Barbet, A.F. 2014. Knockout of an outer membrane protein operon of anaplasma marginale by transposon mutagenesis. Biomed Central (BMC) Genomics. 15:278.
Tularemia without lesions in grey tree squirrels: A diagnostic challenge - (Peer Reviewed Journal)
Nelson, D.D., Haldorson, G.J., Stanton, J.B., Noh, S.M., Bradway, D.S., Mansfield, K.G., Basler, T.V. 2014. Tularemia without lesions in grey tree squirrels: A diagnostic challenge. Journal of Veterinary Diagnostic Investigation. 26(2):312-315.
Protective immunity induced by immunization with a live, cultured anaplasma marginale strain - (Peer Reviewed Journal)
Kenitra Hammac, G., Ku, P., Galletti, M.F., Noh, S.M., Scoles, G.A., Palmer, G.A., Brayton, K.A. 2013. Protective immunity induced by immunization with a live, cultured anaplasma marginale strain. Vaccine. 31:3617-3622.
Identification of multi-locus genetic heterogeneity in anaplasma marginale ss. centrale and its restriction following tick-borne transmission. Reprint Icon - (Peer Reviewed Journal)
Herndon, D.R., Ueti, M.W., Reif, K.E., Noh, S.M., Brayton, K.A., Agnes, J.T., Palmer, G.H. 2013. Identification of multi-locus genetic heterogeneity in anaplasma marginale ss. centrale and its restriction following tick-borne transmission. Infection and Immunity. 81(5):1852-8.
Linkage between anaplasma marginale outer membrane proteins enhances immunogenicity, but is not required for protection from challenge Reprint Icon - (Peer Reviewed Journal)
Noh, S.M., Turse, J., Brown, W.C., Norimine, J., Palmer, G.H. 2013. Cross-linking of anaplasma marginale outer membrane proteins enhances immunogenicity, but is not required for protection from challenge. Vaccine. 20(5):651-656.
Cross-linking of anaplasma marginale outer membrane proteins enhances immunogenicity, but is not required for protection from challenge Reprint Icon - (Peer Reviewed Journal)
Noh, S.M., Turse, J., Brown, W.C., Normine, J., Palmer, G.H. 2013. Cross-linking of anaplasma marginale outer membrane proteins enhances immunogenicity, but is not required for protection from challenge. Vaccine. Clin.Vacc.Immun. 2013. 20(5):651-656.
Subdominant antigens in bacterial vaccines: Am779 is subdominant in the anaplasma marginale outer membrane vaccine but does not associate with protective immunity Reprint Icon - (Peer Reviewed Journal)
Albarrak, S.M., Brown, W.C., Noh, S.M., Reif, K.E., Scoles, G.A., Turse, J.E., Norimine, J., Ueti, M.W., Palmer, G.H. 2012. Subdominant antigens in bacterial vaccines: Am779 is subdominant in the anaplasma marginale outer membrane vaccine but does not associate with protective immunity. PloSONE 7(9):e46372.
Rickettsial entry into host cells: finding the keys to unlock the doors ()
Palmer, G.H., Noh, S.M. 2013. Rickettsial entry into host cells: finding the keys to unlock the doors. Infection and Immunity. 80(11):3746-3747.
Ovine progressive pneumonia virus is transmitted more effectively via aerosol nebulization than oral administration Reprint Icon - (Peer Reviewed Journal)
Herrmann-Hoesing, L.M., White, S.N., Neiswanger-Broughton, L.E., Johnson, W.C., Noh, S.M., Schneider, D.A., Li, H., Taus, N.S., Reynolds, J.O., Truscott, T.C., Dassanayake, R.P., Knowles Jr, D.P. 2012. Ovine progressive pneumonia virus is transmitted more effectively via aerosol nebulization than oral administration. Open Journal of Veterinary Medicine. 2(3):113-119.
Genome-wide screening and identification of antigens for rickettsial vaccine development Reprint Icon - (Peer Reviewed Journal)
Palmer, G.H., Brown, W.C., Noh, S.M., Brayton, K.A. 2011. Genome-wide screening and identification of antigens for rickettsial vaccine development. FEMS Immunology and Medical Microbiology. 64:115-119.
Dermacentor andersoni transmission of Francisella tularensis subsp. novicida reflects bacterial colonization, dissemination and replication coordinated with tick feeding. Reprint Icon - (Peer Reviewed Journal)
Reif, K., Palmer, G.H., Ueti, M.W., Scoles, G.A., Noh, S.M. 2011. Dermacentor andersoni transmission of Francisella tularensis subsp. novicida reflects bacterial colonization, dissemination and replication coordinated with tick feeding.. Infection and Immunity. 79(12):4941-6.
Expression of Anaplasma marginale ankyrin repeat-containing proteins during infection of the mammalian host and tick vector Reprint Icon - (Peer Reviewed Journal)
Solomon, R.S., Schneider, D.A., Brayton, K.A., Ueti, M.W., Graca, T., Futse, J.E., Noh, S.M., Baszler, T.V., Palmer, G.H. 2011. Expression of Anaplasma marginale ankyrin repeat-containing proteins during infection of the mammalian host and tick vector. Infection and Immunity. 79(7):2847-2855.
Emerging perspectives in the research of bovine Babesiosis and Anaplasmosis Reprint Icon - (Peer Reviewed Journal)
Suarez, C.E., Noh, S.M. 2011. Emerging perspectives in the research of bovine Babesiosis and Anaplasmosis. Veterinary Parasitology. 180(102):109-25.
Stability and tick transmission phenotype of gfp-transformed Anaplasma marginale through a complete in vivo infection cycle - (Peer Reviewed Journal)
Noh, S.M., Ueti, M.W., Palmer, G.H., Munderloh, U.G., Felsheim, R.F., Brayton, K.A. 2010. Stability and tick transmission phenotype of gfp-transformed Anaplasma marginale through a complete in vivo infection cycle. Applied and Environmental Microbiology. 77(1):330-334.
The immunization-induced antibody response to the Anaplasma marginale major surface protein 2 and its association with protective immunity - (Peer Reviewed Journal)
Noh, S.M., Zhuang, Y., Futse, J.E., Brown, W.C., Brayton, K.A., Palmer, G.H. 2010. The immunization-induced antibody response to the Anaplasma marginale major surface protein 2 and its association with protective immunity. Vaccine. 28:3741-3747.
Ovine Progressive Pneumonia Virus Capsid Antigen as Found in CD163- and CD172a-Positive Alveolar Macrophages of Persistently Infected Sheep - (Peer Reviewed Journal)
Hoesing, L.M., Noh, S.M., Snekvik, K.R., White, S.N., Schneider, D.A., Truscott, T.C., Knowles Jr, D.P. 2010. Ovine Progressive Pneumonia Virus Capsid Antigen as Found in CD163- and CD172a-Positive Alveolar Macrophages of Persistently Infected Sheep. Veterinary Pathology. 47(3):518-528.
Peripheral Ovine Progressive Pneumonia Provirus Levels Correlate with and Predict Histological Tissue Lesion Severity in Naturally Infected Sheep - (Peer Reviewed Journal)
Hoesing, L.M., Noh, S.M., White, S.N., Snekvik, K.R., Truscott, T.C., Knowles Jr, D.P. 2009. Peripheral Ovine Progressive Pneumonia Provirus Levels Correlate with and Predict Histological Tissue Lesion Severity in Naturally Infected Sheep. Clinical and Vaccine Immunology. 16(4):551-557.
Composition of the Surface Proteome of Anaplasma marginale and Its Role in Protective Immunity Induced by Outer Membrane Immunization - (Peer Reviewed Journal)
Noh, S.M., Brayton, K.A., Brown, W.C., Norimine, J., Munske, G.R., Davitt, C.M., Palmer, G.H. 2008. Composition of the Surface Proteome of Anaplasma marginale and Its Role in Protective Immunity Induced by Outer Membrane Immunization. Infection and Immunity. 76(5):2219-2226.
Conservation of Transmission Phenotype of Anaplasma marginale (Rickettsiales: Anaplasmataceae) Strains Among Dermacentor and Rhipicephalus Ticks (Acari: Ixodidae) - (Peer Reviewed Journal)
Scoles, G.A., Ueti, M.W., Noh, S.M., Knowles Jr, D.P., Palmer, G.H. 2007. Conservation of Transmission Phenotype of Anaplasma marginale (Rickettsiales: Anaplasmataceae) Strains Among Dermacentor and Rhipicephalus Ticks (Acari: Ixodidae). Journal of Medical Entomology. 44(3):484-491
In vivo Endothelial Cell Infection by Anaplasma marginale - (Peer Reviewed Journal)
Carreno, A.D., Alleman, A.R., Barbet, A.F., Palmer, G.H., Noh, S.M., Johnson, C.M. 2007. In vivo Endothelial Cell Infection by Anaplasma marginale. Veterinary Pathology. 44(1):116-118
DIFFERENTIAL EXPRESSION AND SEQUENCE CONSERVATION OF THE ANAPLASMA MARGINALE MSP2 GENE SUPERFAMILY OUTER MEMBRANE PROTEINS - (Peer Reviewed Journal)
Noh, S.M., Brayton, K.A., Knowles Jr, D.P., Agnes, J.T., Dark, M.J., Brown, W.C., Baszler, T.V., Palmer, G.H. 2006. Differential Expression and Sequence Conservation of the Anaplasma marginale msp2 Gene Superfamily Outer Membrane Proteins. Infection and Immunity. 74(6):3471-3479.