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Research Project: Intervention Strategies to Prevent and Control Crimean-Congo Hemorrhagic Fever (CCHF)

Location: Zoonotic and Emerging Disease Research

Project Number: 3022-32000-021-000-D
Project Type: In-House Appropriated

Start Date: Mar 17, 2021
End Date: Mar 16, 2026

Objective 1. Develop CCHF virus diagnostic tests for the early detection and surveillance of Crimean-Congo Hemorrhagic Fever Virus. Develop viral detection methods for ticks. Develop direct viral detection methods for cattle, sheep, and goats. Develop antibody detection methods to determine CCHF exposure in cattle, sheep, goats, and relevant wildlife. Objective 2. Determine mechanisms of CCHF transmission. Develop CCHF tick and animal infection methods. Develop CCHF tick-animal transmission models. Objective 3. Investigate the epidemiology of CCHF and the role of ticks in maintaining reservoirs of infection in endemic settings. Determine the prevalence of CCHF in vector and animal hosts in endemic areas. Determine the competence of hard tick species in endemic areas. Determining the risk for the establishment of tick host vector in the United States considering climatic and ecological conditions.

The research addresses the following research components in the 2022-2027 Animal Health National Program (NP 103) Action Plan: 1) Component 1: Biodefense, Problem Statement 1A, Control and eradicate foreign animal diseases. The research addresses ARS Strategic Plan Goal 4.3 and the following Performance Measure: Provide scientific information to protect animals, humans, and property from the negative effects of pests and infectious diseases, and develop and transfer tools to the agricultural community, commercial partners, and government agencies to control or eradicate domestic and exotic diseases and pests that affect animal and human health.