Research Project: National Bio and Agro-Defense Facility Scientists Project

Location: Research Programs

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Understanding the molecular mechanisms of attenuation in codon deoptimized FMDV strains - (Abstract Only)
Medina, G.N., Spinard Iii, E.J., Azzinaro, P.A., Rodriguez-Calzada, M., Rieder, A.E., Diaz San Segundo, F.C., De Los Santos, T.B. 2023. Understanding the molecular mechanisms of attenuation in codon deoptimized FMDV strains. Meeting Abstract. https://doi.org/10.3390/v15061332.

Recoding the genome of FMDV: A path for the development of live attenuated vaccine (LAV) candidates against FMD - (Proceedings)
Medina, G.N., Diaz San Segundo, F.C., De Los Santos, T.B. 2023. Recoding the genome of FMDV: A path for the development of live attenuated vaccine (LAV) candidates against FMD. Global Foot-and Mouth Disease Research Alliance (GFRA). https://doi.org/10.3390/v15061332.

Deletion of H108R reduces virulence of the Georgia strain of African swine fever virus with surviving animals being protected against virulent challenge - (Peer Reviewed Journal)
Vuono, E., Ramirez Medina, E., Silva, E.B., Rai, A., Pruitt, S.E., Espinoza, N.N., Valladares, A., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. Deletion of H108R reduces virulence of the Georgia strain of African swine fever virus with surviving animals being protected against virulent challenge. Journal of Virology. https://doi.org/10.1128/jvi.00545-22.

Experimental infection of domestic pigs with an African swine fever virus field strain isolated in 2021 from the Dominican Republic - (Peer Reviewed Journal)
Ramirez Medina, E., O'Donnell, V., Silva, E.B., Espinoza, N.N., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. Experimental infection of domestic pigs with an African swine fever virus field strain isolated in 2021 from the Dominican Republic. Viruses. https://doi.org/10.3390/v14051090.

Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production - (Peer Reviewed Journal)
Bracci, N., de la Fuente, C., Saleem, S., Pinkham, C., Narayanan, A., Garcia-Sastre, A., Balaraman, V., Richt, J.A., Wilson, W.C., Kehn-Hall, K. 2022. Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production. Virology. 567:65-76. https://doi.org/10.1016/j.virol.2021.12.010.

Large-scale international validation of an indirect ELISA based on recombinant nucleocapsid protein of Rift Valley Fever virus for the detection of IgG antibody in domestic ruminants - (Peer Reviewed Journal)
Paweska, J.T., Jansen Van Vuren, P., Msimang, V., Moustapha Lo, M., Thiongane, Y., Mulumba-Mfumu, L.K., Mansoor, L., Fafetine, J.M., Magona, J., Bazanow, B., Wilson, W.C., Pepin, M., Unger, H., Viljoen, G. 2021. Large-scale international validation of an indirect ELISA based on recombinant nucleocapsid protein of Rift Valley Fever virus for the detection of IgG antibody in domestic ruminants. Viruses. 13(8). Article e1651. https://doi.org/10.3390/v13081651.

Evaluation of biosafety and biosecurity at the National Bio and Agro- Defense Facility using High Reliability Organization system requirements as a standard - (Abstract Only)