Technical Abstract: Anthurium andraeanum is a popular ornamental plant that produces modified leaf structures known as spathes that are brightly colored due to accumulation of anthocyanins. While anthocyanin pigments of the Anthurium genus have been investigated, their other flavonoid constituents have received little attention, with a single known report on the isolation of C-glycosides from A. versicolor. In the work presented here, three flavone 6-C-glycosides were fractionated from crude methanol-HCl extracts from leaves of A. andraeanum using reversed-phase HPLC. One was identified as a known flavone glycoside, embinin. The other two compounds were identified through spectroscopic analysis and chemical transformation and are newly described flavone glycosides, 4’’’-(3,4-dimethoxycinnamoyl)-embinin and 4’’’-ferruloyl-embinin. While 6-C-flavonoid glycosides decorated with ferruloyl and cinnamoyl moieties are not uncommon, in most instances the substitution occurs at the 2 and 6 positions of both C-and O-linked sugars. The particular substitution pattern identified, with attachment at the 4’’’-position of flavone 6-C-glycosides, has not previously been described and is reported here for the first time. To our knowledge this is also the first report of the molecular structure of non-anthocyanin flavonoids from Anthurium andraeanum.