DIOXINS AND OTHER ENVIRONMENTAL CONTAMINANTS IN FOOD
Location: Animal Metabolism-Agricultural Chemicals Research
Title: An ADME study with 2,2'4,4',-tetrabromodiphenyl ether (BDE-47) in chickens.
Submitted to: International Workshop on Brominated Flame Retardants
Publication Type: Abstract Only
Publication Acceptance Date: December 10, 2006
Publication Date: April 24, 2007
Citation: Hakk, H., Huwe, J.K., Larsen, G.L. 2007. An ADME study with 2,2'4,4',-tetrabromodiphenyl ether (BDE-47) in chickens. Meeting Abstract. BFR 2007 4th International Workshop on Brominated Flame Retardants, April 24-27, 2007, Amsterdam, The Netherlands.
Studies in mammals have shown that lipophilic tissues such as adipose and skin are major depots for persistent polybrominated diphenyl ethers (PBDE’s). Since humans commonly consume the skin of a chicken, it was of interest to conduct an adsorption, tissue disposition, metabolism and excretion study in this production avian species with the most persistent PBDE found in biota, i.e. 2,2',4,4'-tetrabromodiphenyl ether (BDE-47). Results demonstrated that, as previously shown in rats and mice, BDE-47 was well absorbed (61% in tissues at 72h), and was distributed both on a % dose basis and a concentration basis to lipophilic tissues, i.e. adipose tissue, skin and GI tract. Metabolism to free metabolites was less than 1% of the dose, although non-extractable urine/feces metabolites accounted for about 12% of the dose. Free metabolites were characterized as being hydroxylated and debrominated. Absorption, tissue distribution and metabolism of BDE-47 in chickens was very similar to that observed in rats and mice, in that adipose tissue and skin remain primary depots for this persistent PBDE.