Submitted to: American Association of Avian Pathologists
Publication Type: Proceedings
Publication Acceptance Date: July 13, 2002
Publication Date: December 31, 2002
Citation: Silva, R.F. 2002. Recombinant vaccines and DNA vaccines--unfulfilled promises. American Association of Avian Pathologists. p. 32-45. Technical Abstract: The poultry industry attempts to control infectious diseases through various means, including appropriate farm management, and the genetic breeding of resistant lines. However, the administration of efficacious vaccines has remained the primary means of controlling most pathogens. Unfortunately, the factory farming used today in the poultry industry has increased chicken densities in poultry houses and subsequently increased both the risk of spreading old pathogens and encouraging the emergence of new pathogens. In this review, we will look at how the advent of recombinant DNA technology promised to provide new classes of more efficacious poultry vaccines. While it is not possible in this review to discuss all poultry pathogens and whether recombinant vaccines could improve existing control strategies, we will look at a few select pathogens, their current vaccines, and whether any existing recombinant vaccines offer opportunities for improvement. Although we will not review the technology of how recombinant DNA vaccines are created, we will discuss possible new strategies to develop yet more novel vaccines and again try to predict whether the future of poultry vaccines lies with conventional vaccines or recombinant DNA vaccines.