ARS | Publication request: INTERVAL MAPPING OF GROWTH IN DIVERGENT SWINE CROSS

Submitted to: Mammalian Genome
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: October 6, 1998
Publication Date: N/A

Interpretive Summary: This study reports genetic loci affecting growth rate on chromosome 1 in domestic swine (Sus Scrofa). Although the findings are reported for swine, they provide initial direction for dissecting growth as a complex mammalian trait. The mouse genome database at the Jackson Laboratory report three candidate genes from regions of mouse and human genomes homologous to SSC1 (GAS - Growth Arrest-Specific Gene-1; TGFBR1 - Transforming Growth FActor-Beta Receptor; Type 1 and IGF1R - Insulin-like Growth Factor 1 Receptor) and therefore helps to identify major genetic factors affecting mammalian growth.

Technical Abstract: A genomic scan of 18 swine autosomal chromosomes was constructed using 119 polymorphic microsatellite (ms) markers to identify quantitative trait loci (QTL) for 11 growth traits in the University of Illinois Meishan x Yorkshire Swine Resource Family. A significant QTL effect was found for post-weaning average daily gain (ADG) between 5.5 and 56 kg of body weight that mapped between markers SW373 and SW1301 near the telomere of chromosome 1 q (SSC1). This QTL effect had a nominal (pointwise) p-value of 0.000007, a genome-wide p-value of 0.012 and accounted for 26% of the F2 phenotypic variance. The same chromosome region also had significant effects on ADG between birth and 56 kg body weight (p-value = .000227) and on ADG between 35 and 56 kg (p-value = .00077). These observations suggest that a significant QTL for post- weaning growth reside on SSC1.