|Myers, M - FDA-CVM|
Submitted to: Journal of Animal Science
Publication Type: Abstract Only
Publication Acceptance Date: June 18, 1996
Publication Date: N/A
Technical Abstract: Pigs were penned individually and restrictively-fed from 20 kg to 55 or 60 kg liveweight. Treatments were: CNT - i.m. daily buffer injected; PST - i.m. daily injected with 100 ug PST/kg liveweight, both treated until 55 kg and then slaughtered; ENDO- CNT - i.v. injected for 7 consecutive days with endotoxin diluent starting at 60 kg; ENDO - i.v. injected for 7 consecutive days with 1 ug ENDO/kg liveweight starting at 60 kg; or ENDO-PST. Pigs evaluated for ENDO effects were fed to 60 kg liveweight anticipating a cachectic weight loss during the 7 days of treatment, however, this was not a consistent response. At slaughter, muscles were dissected from origin to insertion, trimmed of fat, and weighed. Muscles evaluated were the semitendinosus (ST), psoas major (PM), supraspinatus (SS), triceps brachii (TB) and rectus femoris (RF). These muscles differ as to function and fiber type composition. Based on wet muscle weight and mass relative to body weight, PST induced hypertrophy of the ST, PM and TB muscles but not the SS and RF. Only the ST atrophied with ENDO treatment. In combination (ENDO- PST), PST both protected the ST from atrophy and maintained hypertrophy of other muscles. Results of this study suggest that PST effects on growth of the pig are selective for specific muscles and that PST can protect from, but not negate, effects of an ENDO-simulated disease state.