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Title: ANALYSES OF MAB REACTIVE WITH PORCINE CD8

Authors
item Saalmuller A, - TUBINGEN, GERMANY
item Aasted B, - ROYAL VET UNIV, DENMARK
item Canals A, - INIA, MADRID SPAIN
item Dominguez J, - INIA, MADRID, SPAIN
item Goldman Theresa,
item Lunney, Joan
item Mauer S, - INIA, MADRID, SPAIN
item Pescovitz M D, - IN UNIV, INDIANA
item Pospisil R, - PRAGUE, CZECH REPUBLIC
item Salmon H, - INRA, MONNAIE, FRANCE

Submitted to: Veterinary Immunology and Immunopathology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: March 1, 1994
Publication Date: N/A

Interpretive Summary: Based on FCM analyses 6 mAb: 76-2-11 (#004), PT36B (#051), PT81B (#052), PG93A (#053), 11/295/33 (#108) and 11/122/28 (#109) recognizing the porcine CD8 antigen were identified to cluster together in the T5 cluster. Epitope analyses using biotinylated mAb 11/295/33 (#108) and 76-2-11 (#004) led to the determination of two epitopes CD8a and CD8b, the first recognized by mAb 76-2-11 (#004), PT36B (#051) and PT81B (#052); second by mAb PG93A (#053), 11/295/33 (#108) and 11/122/28 (#109). Because of missing data about the molecular mass of the antigen recognized by mAb PT36B (#051), PT81B (#052) and PG93A (#053), these mAb received the prefix "w" for their respective subcluster.

Technical Abstract: Based on FCM analyses 6 mAb: 76-2-11 (#004), PT36B (#051), PT81B (#052), PG93A (#053), 11/295/33 (#108) and 11/122/28 (#109) recognizing the porcine CD8 antigen were identified to cluster together in the T5 cluster. Epitope analyses using biotinylated mAb 11/295/33 (#108) and 76-2-11 (#004) led to the determination of two epitopes CD8a and CD8b, the first recognized by mAb 76-2-11 (#004), PT36B (#051) and PT81B (#052); second by mAb PG93A (#053), 11/295/33 (#108) and 11/122/28 (#109). Because of missing data about the molecular mass of the antigen recognized by mAb PT36B (#051), PT81B (#052) and PG93A (#053), these mAb received the prefix "w" for their respective subcluster.

   
 
 
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