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United States Department of Agriculture

Agricultural Research Service

Research Project: Understanding and Mitigating the Adverse Effects of Poisonous Plants on Livestock Production Systems

Location: Poisonous Plant Research

Title: Cyclopamine: From cyclops lambs to cancer treatment

Authors
item Lee, Stephen
item Welch, Kevin
item Panter, Kip
item Gardner, Dale
item Garrossian, Massoud -
item Chang, Cheng-Wei -

Submitted to: Journal of Agricultural and Food Chemistry
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: April 10, 2014
Publication Date: July 30, 2014
Citation: Lee, S.T., Welch, K.D., Panter, K.E., Gardner, D.R., Garrossian, M., Chang, C.T. 2014. Cyclopamine: From cyclops lambs to cancer treatment. Journal of Agricultural and Food Chemistry. 62(30):7355-7362.

Interpretive Summary: In the late 1960’s, the steroidal alkaloid, cyclopamine, was isolated from the plant Veratrum californicum and identified as the teratogen responsible for craniofacial birth defects including cyclops in the offspring of sheep grazing on mountain ranges in the western United States. Cyclopamine was found to inhibit the hedgehog (Hh) signaling pathway which plays a critical role in embryonic development. More recently, aberrant Hh signaling has been implicated in several types of cancer. Thus, inhibitors of the Hh signaling pathway, including cyclopamine derivatives, have been targeted as potential treatments for certain cancers and other diseases associated with the Hh signaling pathway. A brief history of cyclopamine and cyclopamine derivatives investigated for the treatment of cancer are presented.

Technical Abstract: In the late 1960’s, the steroidal alkaloid, cyclopamine, was isolated from the plant Veratrum californicum and identified as the teratogen responsible for craniofacial birth defects including cyclops in the offspring of sheep grazing on mountain ranges in the western United States. Cyclopamine was found to inhibit the hedgehog (Hh) signaling pathway which plays a critical role in embryonic development. More recently, aberrant Hh signaling has been implicated in several types of cancer. Thus, inhibitors of the Hh signaling pathway, including cyclopamine derivatives, have been targeted as potential treatments for certain cancers and other diseases associated with the Hh signaling pathway. A brief history of cyclopamine and cyclopamine derivatives investigated for the treatment of cancer are presented.

Last Modified: 10/20/2014
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