|Schmidt, Lori - UNIVERSITY OF IOWA|
|Gloer, James - UNIVERSITY OF IOWA|
Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: June 25, 2007
Publication Date: July 31, 2007
Citation: Schmidt, L., Gloer, J., Wicklow, D.T. 2007. Solanapyrone analogues from a Hawaiian fungicolous fungus. Journal of Natural Products. 70(8):1317-1320. Available: http://pubs.acs.org/cgi-bin/article.cgi/jnprdf/2007/70/i08/pdf/np070251m.pdf. Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of novel antifungal agents useful to agriculture and medicine. An unidentified fungus, encountered as a colonist of a wood decay fungus growing on a dead hardwood branch, collected in a montane dry forest in Hawaii County, Hawaii, was examined for its ability to produce antifungal agents and other bioactive metabolites. Solanapyrone J is reported as a new fungal metabolite with significant antifungal activity against Aspergillus flavus, Candida albicans, and Fusarium verticillioides.
Technical Abstract: Four new solanayrone analogues (solanapyrones J-M; 1-4) have been isolated from an unidentified fungicolous fungus collected in Hawaii. The structures and relative configurations of these compounds were determined by analysis of ID NMR, 2D NMR, and MS data. Solanapyrone J(1) showed antifungal activity against Aspergillus flavus and Fusarium verticillioides, while both 1 and 2 showed activity against Staphylococcus aureus and Candida albicans.