Technical Abstract: Understanding of pathogen and insect-elicited plant desistance (i.e., the slowing or ceasing of plant growth) could benefit our breeding programs for developing new peanut germplasm for disease and insect resistance. Biochemical (i.e., peroxidase, esterase, and lipoxygenase activities) and physiological (i.e., photosynthetic rate, and light and CO2 response curves) mechanisms of TSWV-elicited desistance of peanut plants were examined. The desist mechanisms were examined using leaves from the five selected peanut genotypes either with TSWV infection-elicited chlorotic symptoms or without chlorosis (as the control). Enzyme assays showed that the virus-infected chlorotic leaves had a significantly higher peroxidase, esterase, and lipoxygenase activities when compared with the control leaves. In addition, the photosynthetic rate at 70 and 90 days after planting was significantly lower on chlorotic leaves when compared with the control leaves. Furthermore, light and CO2 response curves of photosynthetic rate between the virus-infected and control leaves also showed an intriguing varietal difference. This study indicated that the information of desistance mechanism might be valuable to our understanding of insect and disease resistance mechanisms in peanut.