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United States Department of Agriculture

Agricultural Research Service

Title: A Genome Scan for Qtl Influencing Milk Production and Health Traits in Dairy Cattle

Authors
item Heyen, D - UNIV OF ILLINOIS
item Weller, J - INSTITUTE OF ANIMAL SCI
item Ron, M - INSTITUTE OF ANIMAL SCI
item Band, M - UNIV OF ILLINOIS
item Beever, J - UNIV OF ILLINOIS
item Feldmesser, E - INSTITUTE OF ANIMAL SCI
item Da, Y - UNIV OF ILLINOIS
item Wiggans, George
item Vanraden, Paul
item Lewin, H - UNIV OF ILLINOIS

Submitted to: Genomics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: October 15, 1999
Publication Date: N/A

Interpretive Summary: A genome scan was conducted in the North American Holstein-Friesian population for quantitative trait loci (QTL) affecting production and health traits using the granddaughter design. Resource families consisted of 1,068 sons of eight elite sires. Genome coverage was estimated to be 2,551 cM (85%) for 174 genotyped markers. Each marker was tested for effects on milk yield, fat yield, protein yield, fat percentage, protein percentage, somatic cell score, and productive herd life using analysis of variance. Joint analysis of all families identified marker effects on 11 chromosomes that exceeded the genomewide, suggestive, or nominal significance threshold for QTL effects. Large marker effects on fat percentage were found on chromosomes 3 and 14, and multimarker regression analysis was used to refine the position of these QTL. Half-sibling families from Israeli Holstein dairy herds were used in a daughter design to confirm the presence of the QTL for fat percentage on chromosome 14. The QTL identified in this study may be useful for marker-assisted selection and for selection of a refined set of candidate genes affecting these traits.

Technical Abstract: A genome scan was conducted in the North American Holstein-Friesian population for quantitative trait loci (QTL) affecting production and health traits using the granddaughter design. Resource families consisted of 1,068 sons of eight elite sires. Genome coverage was estimated to be 2,551 cM (85%) for 174 genotyped markers. Each marker was tested for effects on milk yield, fat yield, protein yield, fat percentage, protein percentage, somatic cell score, and productive herd life using analysis of variance. Joint analysis of all families identified marker effects on 11 chromosomes that exceeded the genomewide, suggestive, or nominal significance threshold for QTL effects. Large marker effects on fat percentage were found on chromosomes 3 and 14, and multimarker regression analysis was used to refine the position of these QTL. Half-sibling families from Israeli Holstein dairy herds were used in a daughter design to confirm the presence of the QTL for fat percentage on chromosome 14. The QTL identified in this study may be useful for marker-assisted selection and for selection of a refined set of candidate genes affecting these traits.

Last Modified: 4/20/2014
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