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United States Department of Agriculture

Agricultural Research Service

Title: Kinetic Differences in Intestinal and Systemic Interfon-Gamma and Antigen Specific Antibodies in Chickens Experimentally Infected with Eimeria Maxima

Authors
item Yun, Cheol - NIH BETHESDA MD
item Lillehoj, Hyun
item Zhu, James
item Min, Wongi - USDA, ARS, LPSI, IDRL

Submitted to: American Association of Veterinary Parasitologists Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: April 3, 2000
Publication Date: N/A

Technical Abstract: Recombinant chicken interleukin-2 (IL-2) promotes the growth of T cells in vitro and enhances NK-cell activity in chickens. Stimulation of IL-2- dependent T-cells with Con A induced interferon-gamma (IFNg) and IL-2 mRNA transcripts whereas stimulation with rIL-2 induced only IFN-mRNA. Subcutaneous injection of rIL-2 RNA to day-old chickens increased the percentage of cells which express the CD8 and TCR antigens in the spleen. Chickens which were orally infected with Eimeria acervulina showed a significant enhancement of IL-2 mRNA transcripts in the spleen and intestine and increased percentage of T-cells in the duodenum following both primary and secondary infections. These results indicate that host immune responses to E. acervulina involve an up-regulation of IL-2 secretion and an increased duodenum T-cells. 1

Last Modified: 7/23/2014