Author
WU, ZHAOFEI - University Of Houston | |
KIM, EUR RAN - University Of Houston | |
SUN, HAO - University Of Houston | |
XU, YUANZHONG - University Of Houston | |
MANGIERI, LEANDRA - University Of Houston | |
LI, DE-PEI - Md Anderson Cancer Center | |
PAN, HUI-LIN - Md Anderson Cancer Center | |
XU, YONG - Children'S Nutrition Research Center (CNRC) | |
ARENKIEL, BENJAMIN - Baylor College Of Medicine | |
TONG, QINGCHUN - University Of Houston |
Submitted to: Journal of Neuroscience
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 1/7/2015 Publication Date: 2/25/2015 Citation: Wu, Z., Kim, E., Sun, H., Xu, Y., Mangieri, L., Li, D., Pan, H., Xu, Y., Arenkiel, B., Tong, Q. 2015. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. Journal of Neuroscience. 35(8):3312-3318. Interpretive Summary: Obesity is a serious global health problem. Here we showed that a chemical, namely GABA, can strongly promote food intake through its actions in the brain. These findings suggest that GABA signals in the brain could be a potential target for treatment of obesity. Technical Abstract: Lesions of the lateral hypothalamus (LH) cause hypophagia. However, activation of glutamatergic neurons in LH inhibits feeding. These results suggest a potential importance for other LH neurons in stimulating feeding. Our current study in mice showed that disruption of GABA release from adult LH GABAergic neurons reduced feeding. LH GABAergic neurons project extensively to the paraventricular hypothalamic nucleus (PVH), and optogenetic stimulation of GABAergic LH->PVH fibers induced monosynaptic IPSCs in PVH neurons, and potently increased feeding, which depended on GABA release. In addition, disruption of GABA-A receptors in the PVH reduced feeding. Thus, we have identified a new feeding pathway in which GABAergic projections from the LH to the PVH promote feeding. |