Author
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HADSELL, DARRYL - Children'S Nutrition Research Center (CNRC) |
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Submitted to: Endocrine Society Meeting
Publication Type: Abstract Only Publication Acceptance Date: 1/9/2015 Publication Date: 3/5/2015 Citation: Hadsell, D.L. 2015. Genome-wide association as a means to understanding the mammary gland [abstract]. Endocrine Society's 97th Annual Meeting and Expo, Session: Big Data in Small Systems, March 5-8, 2015, San Diego, California, S77-3. Interpretive Summary: Technical Abstract: Next-generation sequencing and related technologies have facilitated the creation of enormous public databases that catalogue genomic variation. These databases have facilitated a variety of approaches to discover new genes that regulate normal biology as well as disease. Genome wide association (GWAS) is an approach that has been increasingly employed in humans and model systems to identify quantitative trait loci (QTL) that regulate normal biology and disease. Mammary gland development and function is regulated by genetics. From a quantitative standpoint, phenotypes or traits to lactation have been extensively studied in dairy species, but also in humans and mice. In addition, traits including those describing mammary ductal development as well as risk for breast cancer are also heritable and thus regulated by identifiable genomic variation. This seminar will give an overview of GWAS in the mouse, provide examples of it use in mammary gland biology, and discuss both successes and limitations. |
