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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #199607
Title: Leisure Time Physical Activity and Mortality in Chronic Kidney Disease: Preliminary findings from the MDRD study

Author
item CHEN, JOLINE - TUFTS-NEMC
item CASTANEDA-SCEPPA, CARMEN - TUFTS/HNRCA
item RUTHAZER, ROBIN - TUFTS-NEMC
item LEVEY, ANDREW - TUFTS-NEMC

Submitted to: National Kidney Foundation Meeting Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 11/1/2005
Publication Date: 4/1/2006
Citation: Chen, J.L., Castaneda-Sceppa, C., Ruthazer, R., Levey, A.S. 2006. Leisure Time Physical Activity and Mortality in Chronic Kidney Disease: Preliminary findings from the MDRD study. [abstract]. National Kidney Foundation Meeting Proceedings. CM06 Clinical Handbook, NFK Proceedings. 2006:224.

Interpretive Summary:

Technical Abstract: Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease and all-cause mortality. In the general population, physical activity is associated with reduced mortality. We examined physical activity status in CKD patients and its relation to all-cause mortality. The Modified Diet in Renal Disease (MDRD) Study was a multi-center trial that randomized 840 CKD patients between 1989 and 1993 with mortality determined through the end of 2000. We analyzed baseline self-report data from the MDRD/Leisure Time Physical Activity Questionnaire on 834 patients. Based on the Surgeon General’s Recommendations, patients were divided into four patterns of physical activity: 1. regular and intensive; 2: regular and not intensive; 3: irregular; 4: no physical activity. The mean age was 52 years and 61% were male among the study sample. 19%, 19%, 24%, and 38% of patients were identified to have exercise patterns 1-4 respectively. The mean energy expenditure in patterns 1-4 were 12655, 7507, 3976, and 0 KJ/week respectively. Although patients with physical activity pattern 1 were significantly older, had more prior cardiovascular disease and higher blood pressure, there was no significant difference among the groups in GFR, albumin and other cardiovascular diseases factors. A total of 205 patients (24.6%) died during follow up. The unadjusted hazard ratio for all-cause mortality for Pattern 1 was 1.2 (95% CI 0.8-1.7); Pattern 2: 0.7 (0.4-1.2), and Pattern 3: 0.8 (0.6-1.2), in reference to Pattern 4. After adjusting for age, gender, GFR, albumin, prior cardiovascular disease, and BMI, the adjusted hazard ratios for patterns 1–3 , in reference to pattern 4, were 0.8 (0.6-1.2), 0.9 (0.6-1.5), and 1.1 (0.8-1.6). The majority of CKD patients do not participate in any leisure time physical activity. We did not find significant differences among the physical activity and 10 year outcomes. Given the benefit of physical activity in general population, the role of physical activity in health outcomes in CKD requires further study.