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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #213864
Title: Scavenger Receptor Class B Type I (SCARB1) c.1119C>T Polymorphism Affects Postprandial Triglyceride Metabolism in Men

Author
item TANAKA, TOSHIKO - TUFTS/HNRCA
item DELGADO-LISTA, JAVIER - UNIV OF REINA SOFIA, ES
item LOPEZ-MIRANDA, JOSE - UNIV OF REINA SOFIA, ES
item PEREZ-JIMENEZ, FRANCISCO - UNIV OF REINA SOFIA, ES
item MARIN, CARMEN - UNIV OF REINA SOFIA, ES
item PEREZ-MARTINEZ, PABLO - UNIV OF REINA SOFIA, ES
item GOMEZ, PURIFICACION - UNIV OF REINA SOFIA, ES
item Ordovas, Jose

Submitted to: Journal of Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/4/2006
Publication Date: 3/1/2007
Citation: Tanaka, T., Delgado-Lista, J., Lopez-Miranda, J., Perez-Jimenez, F., Marin, C., Perez-Martinez, P., Gomez, P., Ordovas, J.M. 2007. Scavenger Receptor Class B Type I (SCARB1) c.1119C>T Polymorphism Affects Postprandial Triglyceride Metabolism in Men. Journal of Nutrition. 137:578-582.

Interpretive Summary: Much of our knowledge about the relationship between lipid, lipoprotein metabolism and the development of atherosclerosis and cardiovascular disease is based on measurements in the fasting state. However, the postprandial state constitutes the normal metabolic situation of human beings throughout the day in developed societies due to successive meal intakes along the day. Postprandial lipoprotein metabolism is modulated by dietary pattern, several lifestyle conditions (physical activity, smoking and alcohol consumption), physiological factors (age, gender, menopausal status) and pathological conditions (diabetes mellitus, insulin resistance, obesity). Several lines of evidence suggest that postprandial lipemia increases the risk of atherogenesis and the roles of many genes have been explored in order to establish the possible implications of their variability in coronary heart disease risk. Scavenger receptor class B type I (SCARB1) is a receptor that plays an integral part in cholesterol homeostasis cholesterol. We have investigated the relation between blood lipids following the consumption of a meal and the SCARB1 polymorphisms in the SCARB1gene. Our data show that this mutation modulates the response to fat intake and this information can be used to provide more personalized dietary recommendations to prevent heart disease.

Technical Abstract: The scavenger receptor class B type I (SCARB1) is a cell surface glycoprotein that plays a key role in reverse cholesterol transport. A polymorphism in exon 8 (c.1119C>T) has been associated with fasting HDL- and LDL- cholesterol concentrations in Caucasian populations. This study evaluated whether this variant is associated with postprandial lipemia in 59 normolipidemic males. After an overnight fast, the subjects were given a single fat load comprising 60% of energy as fat, 15% as protein, and 25% as carbohydrate. Blood was drawn every hour from baseline to 6 h, then every 2.5 h until h 11. We measured plasma lipid concentrations including triglycerides (TG) in large and small triglyceride rich lipoprotein particles (TRL). Changes in postprandial small TRL TG differed among groups over time (Pgeno x time = 0.034) whereby TT and CT subjects maintained lower concentrations throughout most of the postprandial period compared with CC subjects. Significant differences occurred at h 1, 2, 4, and 5 (P < 0.05). Postprandial changes in large TRL TG (Pgeno x time = 0.923) or total TG (Pgeno x time = 0.529) did not differ by genotype. These results suggest that the c.1119C>T polymorphism is associated with a lower postprandial TG response in the smaller, partially catabolized lipoprotein fraction.