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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #195393
Title: IMPACT OF SOYBEAN OILS VARYING IN FATTY ACID PROFILE ON T CELL PROLIFERATION OF MODERATELY HYPERLIPIDEMIC SUBJECTS

Author
item HAN, SUNG NIM - TUFTS/HNRCA
item Lichtenstein, Alice
item WU, DI - TUFTS/HNRCA
item AUSMAN, LYNNE - TUFTS/HNRCA
item Meydani, Simin

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 4/1/2005
Publication Date: 4/1/2005
Citation: Han, S., Lichtenstein, A.H., Wu, D., Ausman, L.M., Meydani, S.N. 2005. Impact of soybean oils varying in fatty acid profile on t cell proliferation of moderately hyperlipidemic subjects. Federation of American Societies for Experimental Biology Conference.20:A123.

Interpretive Summary:

Technical Abstract: Linoleic acid and alpha linolenic acid are essential fatty acids, which play an important role in modulation of T cell proliferation. We studied the effects of feeding selectively bred and genetically modified soybean oils distinguished by altered fatty acid profiles, resulting in varied linoleic/linolenic ratios, on proliferative response of T cells from adults using a double-blind, randomized design. Eighteen subjects (>50 years old) with elevated cholesterol levels (130-160 mg/dL LDL cholesterol) consumed five experimental diets for periods of 35 days each in a random order; each diet contained 30% of energy as fat, of which 2/3 was either high oleic acid SO (HiOleic-SO), soybean oil (SO), low saturated fatty acid SO (LoSFA-SO), hydrogenated SO (Hydrog-SO), or low alpha-linolenic acid SO (LoALA-SO) (linoleic/linolenic ratios of 0.86, 8.5, 9.2, 13.9, 20.3, respectively). Subjects exhibited significantly higher proliferative response to PHA compared to their own baseline following consumption of SO, LoSFA-SO, or HiOleic-SO. On the other hand, T cell proliferative response was similar to the baseline after subjects consumed the diets with linoleic/linolenic acids ratio greater than 10 (Hydrog-SO and LoALA-SO). An inverse correlation between ratio of linoleic/linolenic acids and T cell proliferative response to PHA after diet intervention was observed. Optimal proliferative response was observed at linoleic/linolenic acid ratio of 8.5. These effects were independent of changes in prostaglandin (PG) E2 production and might reflect the effect of these fatty acids on membrane lipid composition and function.