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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Publications at this Location » Publication #186167
Title: BOVINE TUMOR NECROSIS FACTOR RECEPTOR-1 AND METHODS OF USE

Author
item TAYLOR, MICHAEL - IOWA STATE UNIVERSITY
item Kehrli Jr, Marcus
item LEE, EUN-KYUNG - IOWA STATE UNIVERSITY

Submitted to: Patent Application
Publication Type: Patent Application
Publication Acceptance Date: 6/18/2002
Publication Date: 6/18/2002
Citation: Taylor, M.J., Kehrli, Jr., M.E., Lee, E. 2002. Bovine tumor necrosis factor receptor-1 and methods of use. U.S. Patent 6,406,907 B1.

Interpretive Summary:

Technical Abstract: The invention relates to nucleic acid sequences encoding a bovine tumor necrosis factor receptor-1 (TNF-R1). Also within the invention is a soluble bovine TNF-R1, which is a potent inhibitor of bovine tumor necrosis factor-alpha (TNF-alpha). The invention demonstrates that soluble bovine TNF-R1 has therapeutic value as an inhibitor of TNF in cattle suffering from coliform mastitis or other inflammatory disease. This invention focuses on nucleic acid sequences (or closely related sequences) expressed in host cells or vectors or both that enable delivery of the TNF-R1 capable of inhibiting TNF-alpha.