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United States Department of Agriculture

Agricultural Research Service

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Research Project: Health Promoting Roles of Food Bio-Active Phenolic Compounds on Obesity-Altered Heart, and Kidney Functions and Physiology

Location: Diet, Genomics and Immunology Lab

Project Number: 1235-51000-057-00
Project Type: Appropriated

Start Date: Mar 16, 2014
End Date: Mar 15, 2019

Objective:
Obesity is a serious health condition, often associated with grave consequences on several chronic diseases such as diabetes, insulin resistance, cardiovascular disease, hypertension, chronic kidney disease (CKD), and other dysfunctions. U.S. government statistics show nearly two-thirds of U.S. adults are overweight and with half of them considered obese. Therefore, this plan is based on the hypothesis that diets containing phenolics and their natural derivatives help decrease risk factors of hypertension, CKD and their related events via improving obesity and its associated conditions. The objectives of this plan are: Objective 1: Determine the extent to which obesity-induced hypertension can be attenuated by polyphenolic compounds (focusing on caffeic acid, ferulic acid, chlorogenic acids and their natural derivatives) found in grains and vegetables. Objective 2: Determine the extent to which obesity-induced impaired kidney function can be attenuated by polyphenolic compounds (focusing on caffeic acid, ferulic acid, chlorogenic acids and their natural derivatives) found in grains and vegetables.

Approach:
The extent to which obesity-induced hypertension can be reduced by polyphenolic compounds (focusing on caffeic acid, ferulic acid, chlorogenic acids, and their natural derivatives) found in grains and vegetables will be evaluated by attenuating subclinical inflammation and its related events by caffeic acid, ferulic acid, chlorogenic acids, protocatechuic acid, and their natural derivatives found in plants including grains and vegetables in an animal model. Regulation of COX enzymes, NF-kB, peroxynitrite, ox-LDL, p38, MCP-1, IL-6, TNF-alpha, and angiotensin will be investigated as mechanisms of action in-vivo. The extent to which obesity-induced impaired kidney function can be attenuated by polyphenolic compounds (focusing on caffeic acid, ferulic acid, chlorogenic acids, and their natural derivatives) found in grains and vegetables will also be determined via reactive oxygen species (ROS) investigating regulation of AGEs, p38, MCP-1, TGF-beta, EMT, and adiponectin-mediated pathways as mechanisms of action in in vitro models.

Last Modified: 10/1/2014
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