Location: Foreign Animal Disease Research
Project Number: 8064-32000-058-00
Start Date: Oct 27, 2011
End Date: Oct 26, 2016
1. To examine the virus-vector-host interactions responsible for virulence and transmission, studies will be conducted to determine tissue tropism in cattle after viral infection through insect bite, and the events mediating viral infection, early pathogenesis and transmission. The mechanisms of insect-to-insect transmission while co-feeding in cattle will be characterized and the role of cattle of amplifying hosts for VSV will be assessed. Tests will be conducted to determine the level of potentiation of VSV infection by black fly (Simulium Vittatum) salivary gland factors. Studies will be conducted on the virulence and transmissibility of VSV strains making incursions into northern Mexico. 2. Viral strains circulating in endemic areas of Mexico will be genetically characterized, and the epidemiological and ecological factors associated with emergence and maintenance of the specific viral genetic lineages in endemic settings will be analyzed in comparison to non-endemic virus strains.