Location: Aquatic Animal Health Research
Project Number: 6420-32000-024-10
Start Date: Dec 01, 2009
End Date: Nov 30, 2014
Bacterial vaccines will be developed using molecular and immunological techniques that may identify immunodominant antigens which are responsible for protective immunity in fish. ARS has developed and published techniques for detection of immunodominant antigens and methods used in the evaluation of immune responses and immune response genes. The ARS research will aid in the development and evaluation of fish vaccines against the selected pathogens. The vaccines to be developed include killed, oral, recombinant and modified live types depending on the requirements of the producer. ARS has developed and published methods for detection and identification of fish pathogens using molecular and immunological based methods. Diagnostic tools will be developed and evaluated for fish pathogen of mutual interest. ARS has published in immune gene research and we will mutually conduct gene expression quantitative measure using RNA, real-time PCR and molecular biological techniques with the cooperator.