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United States Department of Agriculture

Agricultural Research Service

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Research Project: Epidemiological Analysis of Fmd Virus in Uganda

Location: Foreign Animal Disease Research

Project Number: 1940-32000-057-62
Project Type: Specific Cooperative Agreement

Start Date: Jan 01, 2014
End Date: Mar 03, 2015

Objective:
Foot-and-Mouth Disease (FMD) is a high priority transboundary disease that severely impairs animal health and livestock production in sub-Saharan African nations. The objective of this research project is to support surveillance capabilities of collaborators from the Uganda Virus Research Institute (UVRI) and Makarere University (MU) of Uganda in cooperation with the Ugandan Ministry of Agriculture, Animal Industry and fisheries (MAAIF). It will also contribute to generate knowledge on the epidemiology of the disease, such as viral characterization and diagnostic test development, that will ultimately help to prevent and control FMD in the region. The goal of this collaborative research project is to provide epidemiological support to USDA, ARS in the design, execution, and data analysis for FMD-related projects in Uganda. Specific objectives include: 1. Design observational studies to assess, in quantitative terms, the epidemiological dynamics of FMD in Uganda. 2. Quantify the spatial distribution of FMD prevalence in Uganda, as long as its association with epidemiological factors. 3. Quantify the transmission rate of FMD in Uganda. 4. Identify associations between the variation in number of nucleotides within the P1 gene of FMD virus provided by ARS collaborators in Uganda and other African collaborators and the features of the host population that were associated with changes in the virus sequences. 5. Contribute to building technical capacity for UVRI and MU and other institutions in Uganda related to strengthening the FMD surveillance program in the country.

Approach:
1. The University of Minnesota will provide epidemiological expertise to USDA, ARS in the design of studies to collect data, and will collaborate with the analysis of data (input data) collected and generated in this project to produce knowledge and information (output) that will help to support FMD control and prevention in the region. 2. Input data to be shared with the University of Minnesota will include: a. Sequence data and tests results. b. Epidemiological information collected through the studies designed in collaboration with the University of Minnesota. 3. Outputs to be provided by the University of Minnesota will include: a. Estimates of the spatial distribution of FMD in Uganda, and of its association with epidemiological factors; b. Estimates of the transmission rate of FMD in Uganda. c. Assessment, in quantitative terms, of (1) the relation between nucleotide variation in the P1 sequences of the virues provided by Ugandan collaborators and USDA, ARS and the epidemiological factors hypothesized to be associated with such variation; (2) the geographical variation of FMD risk in Uganda and its association with epidemiological factors; (3) areas to gather field samples of FMD in endemic regions of Uganda for analysis and surveillance (targeted surveillance). 4. Scientists from UVRI and MU and other individuals in the field will be trained in epidemiological aspects of FMDV infection, along with sample collection mechanisms and shipment.

Last Modified: 9/1/2014
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