Development of a Prebiotic Intervention to Reduce Carriage of Zoonotic Pathogens of Swine During on-Farm Rearing and Entering the Abattoir
Food and Feed Safety Research
Project Number: 3091-32000-030-66
Start Date: May 01, 2014
End Date: Oct 30, 2015
1) Determine the inhibitory concentration of thymol-beta-D-glucopyranoside (called beta-D-thymol) needed to achieve efficacious reductions of Campylobacter coli, Salmonella spp., and E. coli in laboratory and animal feeding studies.
2) Evaluate the potential of beta-D-thymol to co-select for antibiotic-resistant Campylobacter coli, Salmonella spp., and generic E. coli or to make resistant strains of these bacteria more sensitive to antibiotics when grown in mixed populations of porcine gut bacteria.
A series of laboratory and live animal studies will be conducted to test the effects of a novel antimicrobial compound, thymol-beta-D-glucopyranoside, on the survivability and antimicrobial susceptibility of zoonotic pathogens.