1a.Objectives (from AD-416):
ARS and the Cooperator are interested in better understanding how diet and lifestyle can contribute to regulating energy substrate utilization and the prevention of obesity and diabetes. The objective of this cooperative activity is to examine the relationship of physical activity to fuel management and glucose regulation. Ambulatory monitoring (AM) methodologies and mathematical modeling of physiological processes used in this project can provide important information for the study of these national health problems.
1b.Approach (from AD-416):
Both parties are involved in independent research projects which examine the relationship of specific metabolic parameters to fuel use by the individual and the development of methods to assess current status of fuel stores in free-living humans. The objective of this cooperation is the developmet of mathematical models and data processing routines which relate real-time measurement of relevant metabolic parameters to fuel metabolism and in particular glucose regulation. The parties agree that meeting the objectives of this project will strengthen and enhance ongoing research within the scope of this agreement.
Through this agreement, we are working to develop advanced mathematical models to predict the water and metabolic fuel requirements of physically active humans. This agreement serves to combine the expertise of ARS in conducting nutrition studies of energy regulation with the exercise physiology expertise of the Department of Exercise Science at George Washington University and the mathematical modeling expertise and interests of the Department of Defense. Through this collaboration, we are developing advanced mathematical models to predict the water and metabolic fuel requirements of physically active humans. A study was conducted to determine glucose regulation and substrate oxidation patterns in 10 people, aged 65 - 75 who were untrained with a slightly impaired glucose tolerance. Walking after each meal was significantly more effective than 45 min of sustained walking in the morning or afternoon in lowering post-dinner glucose. These data were used to develop mathematical models of substrate oxidation patterns and to investigate the lag time associated with switching from one metabolic fuel to another.