2010 Annual Report 1a.Objectives (from AD-416) To determine the influence of cranberry on risk factors for cardiovascular disease. Objective 2 “Determine the ability of plant-based dietary components to reduce oxidative stress, inflammation, DNA damage, glucoregulation, and blood pressure, and define the inter-individual variation in these responses as well as the genetic basis for the variation.” 1b.Approach (from AD-416) ARS will conduct a randomized clinical trial to investigate the effect of cranberry polyphenols on risk factors (such as inflammatory markers, lipids, lipoproteins, blood pressure) for cardiovascular disease. A cranberry extract will be used in order to conduct this study to ensure that the study is double blinded. 3.Progress Report This is a new project to assess the impact of cranberry juice of cardiovascular disease risk factors. Recruitment for a human intervention study is underway. Activities and progress of this Agreement are monitored through site visits, conference calls, and email correspondence.