2010 Annual Report
2. Develop a standard method for processing fermented noni juice.
This report documents research conducted under a Trust Agreement between ARS and the Patient-First Cancer Foundation. Research was conducted towards determining the quality, safety and bioactivity of processed noni juice. Noni fruit were harvested from Kawaihae, HI and fermented in sterile, covered glass jars for up to 4 weeks. Prominent micro-organisms present in fresh and fermented batchs of noni juice were isolated and characterized. Fresh (non-pasteurized) noni juice contained Enterobacteriaceae bacteria (Serratia marcescens, Enterobacter cloacae, and E. sakazakii). Fermented (non-pasteurized) noni juice harbored non-Enterobacteriaceae strains (Aeromonas sp. and Pasteurella sp.) and a fungal endophyte which were not present in fresh juice. No micro-organisms were recovered in pasteurized noni juice samples. Pasteurized fermented noni juice showed significant antitumor activity in mice by collaborators, and tests were begun to identify the active fraction(s) of partitioned noni juice.
The ADODR monitors progress through regular meetings with cooperators, and through direct supervision of the research project and participation in research activities.