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United States Department of Agriculture

Agricultural Research Service

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Research Project: GENETIC BASIS OF CYPRINID HERPES VIRUS-3 RESISTANCE IN COMMON CARP

Location: Cool and Cold Water Aquaculture Research

2010 Annual Report


1a.Objectives (from AD-416)
To identify genes associated with viral disease resistance in Carp.


1b.Approach (from AD-416)
Candidate immune response genes will be added on to a genetic linkage map that will contain QTL for viral disease resistance in carp.


3.Progress Report

The common carp is the most important farmed freshwater fish species in the world, including the closely related Ornamental carp (koi). Recently carp producers have suffered enormous economic losses due to a viral disease caused by Cyprinid herpes virus 3 (CyHV-3). Mapping and identification of candidate genes for viral disease resistance in carp will provide insight into the underlying mechanisms of viral resistance. A common carp reference mapping family was genotyped using 45 single nucleotide polymorphic markers representing genes known to be involved in mammalian innate immunity. These genetic markers will be incorporated with 300 additional markers at the HEBREW UNIVERSITY OF JERUSALEM to generate a reference genetic map. The reference map will be used in future genetic analyses to identify genes providing resistance to CyHV-3 in carp. In addition, full-length transcripts of the carp Toll-Like Receptor 9 (TLR9) and two duplicated genes from its signaling pathway were isolated and their expression profiles characterized in common carp and koi.

The ADODR is in frequent contact with the cooperator through phone calls, email, and annual site visits in addition to receipt of written reports.


Last Modified: 7/22/2014
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